6-phenyl-cyclohex-1-enecarboxylic acid | 108298-99-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-phenyl-cyclohex-1-enecarboxylic acid
• 英文别名: 6-Phenyl-cyclohex-1-encarbonsaeure；6-phenylcyclohexene-1-carboxylic acid
• CAS: 108298-99-3
• 化学式: C₁₃H₁₄O₂
• 分子量: 202.253
• InChiKey: XVJFBTHKXAQQMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 、 溶剂黄146 作用下， 生成 6-phenyl-cyclohex-1-enecarboxylic acid
  参考文献：
  名称：

  The Dehydration of 2-Phenylcyclohexanone Cyanohydrin: 6-Phenyl-Δ¹-cyclohexenecarbonitrile and 2-Phenyl-Δ¹-cyclohexenecarbonitrile

  摘要：

  DOI：

  10.1021/jo01107a013

文献信息

• Mechanochemical Birch Reduction with Low Reactive Alkaline Earth Metals
  作者：Jagadeesh Varma Nallaparaju、Riin Satsi、Danylo Merzhyievskyi、Tatsiana Jarg、Riina Aav、Dzmitry G. Kananovich

  DOI：10.1002/anie.202319449

  日期：2024.5.13

  Mechanochemical activation boosts reducing power of magnesium and calcium, allowing to utilize these metals as expedient reductants in ammonia-free Birch reaction in a ball mill at ambient conditions.

  机械化学活化提高了镁和钙的还原能力，允许在环境条件下在球磨机中的无氨 Birch 反应中利用这些金属作为有利的还原剂。
• Sigmoid and transverse sinus thrombosis after closed head injury presenting with unilateral hearing loss
  作者：D. Brors、M. Schäfers、B. Schick、S. Dazert、W. Draf、G. Kahle

  DOI：10.1007/pl00006045

  日期：2001.2.5

  Sinus thrombosis has rarely been associated with closed head injury; more often, thrombosis of the sigmoid or transverse sinus is caused by otogenic inflammations or tumours, or occurs during pregnancy. Symptoms are frequently vague, while untreated thrombus progression may be fatal due to venous congestion and infarction. We report a 32-year-old man presenting with right hearing loss, tinnitus and headache 2 days after a closed head injury. Neurological examination showed no additional abnormality. The EEG showed focal bifrontal slowing. CT revealed a fracture of the occipital bone. MRI and MRA demonstrated complete thrombosis of the right sigmoid and transverse sinuses. After 2 weeks of intravenous heparin therapy followed by warfarin, the patient's hearing improved and MRI and MRA showed complete recanalisation of the sigmoid and transverse sinuses. Venous sinus thrombosis can be an undetected sequel to head injury. Appropriate imaging studies should be carried out to enable therapy to be started as soon as possible.