(R)-8-Oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-3-[(E)-2-(2,2,2-trifluoro-ethylcarbamoyl)-vinyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester | 460739-11-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-8-Oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-3-[(E)-2-(2,2,2-trifluoro-ethylcarbamoyl)-vinyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS: 460739-11-1
• 化学式: C₃₁H₂₄F₃N₃O₄S
• 分子量: 591.61
• InChiKey: PIKHWMOUOIPNTI-KYPPEINGSA-N

反应信息

• 作为反应物：
  描述：

  (R)-8-Oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-3-[(E)-2-(2,2,2-trifluoro-ethylcarbamoyl)-vinyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 在 间氯过氧苯甲酸 作用下， 生成 (R)-5,5,8-Trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-3-[(E)-2-(2,2,2-trifluoro-ethylcarbamoyl)-vinyl]-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
  参考文献：
  名称：

  Cephalosporin-derived inhibitors of β-Lactamase. Part 4: The C3 substituent

  摘要：

  New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00205-6
• 作为产物：
  描述：

  2,2,2-三氟乙基胺 、 在 TEA 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以 乙腈 为溶剂， 生成 (R)-8-Oxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-3-[(E)-2-(2,2,2-trifluoro-ethylcarbamoyl)-vinyl]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
  参考文献：
  名称：

  Cephalosporin-derived inhibitors of β-Lactamase. Part 4: The C3 substituent

  摘要：

  New C3-substituted beta-lactamase inhibitors were prepared and evaluated against representative class A and class C enzymes. It was possible to improve simultaneous inhibitory activity of both classes of serine hydrolase. Other inhibitors showed high selectivity for either the class C cephalosporinases or the class A penicillinases. This represents the first time that cephalosporin-derived inhibitors have demonstrated selectivity for the class A beta-lactamases. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00205-6