(Z) N-(4'methyl-2',5'-dimethoxyphenyl)formamidine | 154843-27-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z) N-(4'methyl-2',5'-dimethoxyphenyl)formamidine
• CAS: 154843-27-3
• 化学式: C₁₂H₁₈N₂O₂
• 分子量: 222.287
• InChiKey: NTNVPMJANJIBNF-JYRVWZFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  16.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  34.06
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (Z) N-(4'methyl-2',5'-dimethoxyphenyl)formamidine 在 silica gel 作用下， 以 乙醚 、 Petroleum ether 为溶剂， 反应 1.0h， 以6%的产率得到2,5-二甲氧基-4-甲基苯胺
  参考文献：
  名称：

  New findings on the Vilsmeier-Haack approach to quinoline derivatives

  摘要：

  The presence of electron-releasing substituents on the aromatic ring of anilides. although necessary for the Vilsmeier-Haack cyclization to quinolines to proceed efficiently, can cause failure of the expected cyclization. leading to (Z) N,N-dimethylformamidines through an alternative course. A similar behaviour is observed when pi-donor groups are introduced on the alpha position of the anilide, although in this case some cyclization to quinoline derivatives generally occurs.

  DOI：

  10.1016/s0040-4020(01)80253-2
• 作为产物：
  描述：

  2,5-二甲氧基-4-甲基苯胺 在 三氯氧磷 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 (Z) N-(4'methyl-2',5'-dimethoxyphenyl)formamidine
  参考文献：
  名称：

  New findings on the Vilsmeier-Haack approach to quinoline derivatives

  摘要：

  The presence of electron-releasing substituents on the aromatic ring of anilides. although necessary for the Vilsmeier-Haack cyclization to quinolines to proceed efficiently, can cause failure of the expected cyclization. leading to (Z) N,N-dimethylformamidines through an alternative course. A similar behaviour is observed when pi-donor groups are introduced on the alpha position of the anilide, although in this case some cyclization to quinoline derivatives generally occurs.

  DOI：

  10.1016/s0040-4020(01)80253-2