2'-甲氧基-尿苷三磷酸 | 143028-99-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 中文名称: 2'-甲氧基-尿苷三磷酸
• 英文名称: 2'-O-methyluridine 5'-triphosphate
• 英文别名: 2'-O-methyl UTP；2'-O-Me-UTP；2'-o-Methyluridine-5'-triphosphate；[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 143028-99-3
• 化学式: C₁₀H₁₇N₂O₁₅P₃
• 分子量: 498.171
• InChiKey: BQJWHJWAEOHVCK-ZOQUXTDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  248
• 氢给体数：
  6
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-3-(4-tert-butyl-benzoyl)-1H-pyrimidine-2,4-dione 生成 2'-甲氧基-尿苷三磷酸
  参考文献：
  名称：

  Novel solid phase synthesis of 2'-o-methylribonucleoside 5'-triphosphates and their α-thio analogues

  摘要：

  Simple, versatile and convenient syntheses of 2'-0-methyl-ribonucleoside 5'-triphosphates have been accomplished on controlled pore glass (CPG) in good yield (>60%) using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one (salicyl phosphorochloridite). Moderate yields were obtained for the corresponding alpha-thiotri-phosphates.

  DOI：

  10.1016/s0040-4039(00)92072-0

文献信息

• Aptamer-toxin molecules and methods for using same
  申请人：——

  公开号：US20040249130A1

  公开（公告）日：2004-12-09

  Materials and methods are provided to prepare therapeutic conjugates for the treatment of proliferative diseases. The therapeutic conjugates of the invention comprise a targeting moiety conjugated to a therapeutic moiety. The therapeutic moiety of the conjugates of the present invention have a cytotoxic effect and are useful in the treatment of proliferative diseases.

  提供了用于治疗增生性疾病的治疗结合物的材料和方法。本发明的治疗结合物包括与治疗物质结合的靶向基团。本发明的结合物的治疗物质具有细胞毒作用，并可用于治疗增生性疾病。
• Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics
  申请人：Diener John L.

  公开号：US20090105172A1

  公开（公告）日：2009-04-23

  The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.

  本发明提供了稳定的、高亲和力的核酸配体，用于与PSMA结合。本文描述了使用2'-O-甲基取代核酸的SELEX™方法和细胞表面SELEX™方法，鉴定和制备新的、稳定的、高亲和力的PSMA配体的方法。还包括使用所述核酸配体治疗和诊断PSMA表达疾病的方法和组合物。
• Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
  申请人：Diener L. John

  公开号：US20070041901A1

  公开（公告）日：2007-02-22

  The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.

  本发明提供了稳定的、高亲和力的核酸配体与PSMA结合。本文介绍了使用2'-O-甲基取代核酸的SELEX™方法以及细胞表面SELEX™方法鉴定和制备新型、稳定、高亲和力的PSMA配体的方法。还包括使用所述核酸配体进行治疗和诊断PSMA表达性疾病的方法和组合物。
• 5'Triphosphate oligonucleotide induces anti-viral response
  申请人：Hartmann, Gunther, Prof. Dr.

  公开号：EP1920775A1

  公开（公告）日：2008-05-14

  Oligonucleotides bearing 5' triphosphate are recognized by RIG-I, leading to the induction of type I IFN production. Bacterial RNA also induces type I IFN production. 5' triphosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, in particular, type I IFN production, in vitro and in vivo and for treating various disorders and diseases including viral infections, bacterial infections, and tumors. Furthermore, oligonucleotides bearing 5' triphosphate can induce IL-18 and IL-1β production, and are thus useful in the treatment of various disorders and dieases such as allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

  含有 5' 三磷酸的寡核苷酸会被 RIG-I 识别，从而诱导 I 型 IFN 的产生。细菌 RNA 也能诱导 I 型 IFN 的产生。5' 三磷酸寡核苷酸和细菌 RNA 可用于体外和体内诱导抗病毒反应或抗菌反应，特别是 I 型 IFN 的产生，并可用于治疗各种疾病，包括病毒感染、细菌感染和肿瘤。此外，含有 5' 三磷酸的寡核苷酸可诱导 IL-18 和 IL-1β 的产生，因此可用于治疗各种紊乱和疾病，如过敏、自身免疫性疾病、免疫缺陷和免疫抑制。
• 5' triphosphate oligonucleotide induces anti-viral response
  申请人：Hartmann, Gunther

  公开号：EP2338499A1

  公开（公告）日：2011-06-29

  Oligonucleotides bearing 5' triphosphate are recognized by RIG-I, leading to the induction of type I IFN production. Bacterial RNA also induces type I IFN production. 5' triphosphate oligonucleotides and bacterial RNA can be used for inducing an anti-viral response or an anti-bacterial response, in particular, type I IFN production, in vitro and in vivo and for treating various disorders and diseases including viral infections, bacterial infections, and tumors. Furthermore, oligonucleotides bearing 5' triphosphate can induce IL-18 and IL-1β production, and are thus useful in the treatment of various disorders and dieases such as allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

  含有 5' 三磷酸的寡核苷酸会被 RIG-I 识别，从而诱导 I 型 IFN 的产生。细菌 RNA 也能诱导 I 型 IFN 的产生。5' 三磷酸寡核苷酸和细菌 RNA 可用于体外和体内诱导抗病毒反应或抗菌反应，特别是 I 型 IFN 的产生，并可用于治疗各种疾病，包括病毒感染、细菌感染和肿瘤。此外，含有 5' 三磷酸的寡核苷酸可诱导 IL-18 和 IL-1β 的产生，因此可用于治疗各种紊乱和疾病，如过敏、自身免疫性疾病、免疫缺陷和免疫抑制。