2-[4-(4-[2-propylguanidino]pyrimid-2-yl)butyl]-5-methyl-4-hydroxypyrimidine | 85583-67-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[4-(4-[2-propylguanidino]pyrimid-2-yl)butyl]-5-methyl-4-hydroxypyrimidine
• 英文别名: 1-[2-[4-(5-methyl-6-oxo-1H-pyrimidin-2-yl)butyl]pyrimidin-4-yl]-2-propylguanidine
• CAS: 85583-67-1
• 化学式: C₁₇H₂₅N₇O
• 分子量: 343.432
• InChiKey: OBIGJQNUTQUTTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Amidine derivatives
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0067508A1

  公开（公告）日：1982-12-22

  This invention relates to amidine derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I:- in which R' is hydrogen or a 1-10C alkyl, 3-8C cycloalkyl, 4.14C cycloalkylalkyl, 3-6C alkenyl, 3-6C alkynyl, 1-6C alkanoyl, 6-10C aryl, 7-11C aralkyl or 7-11C aroyl radical, the latter three being optionally substituted; ring X is a heterocyclic ring as defined in the specification; A is phenylene or 5-7C cycloalkylene or a 1-8C alkylene chain into which is optionally inserted one or two groups; and R2 and R3 are a variety of radicals described in the specification: and the pharmaceutically-acceptabie acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.

  本发明涉及组胺 H-2 拮抗剂和抑制胃酸分泌的脒衍生物。根据本发明提供了一种式 I 的胍衍生物 其中 R' 是氢或 1-10C 烷基、3-8C 环烷基、4.14C环烷基、3-6C烯基、3-6C炔基、1-6C烷酰基、6-10C芳基、7-11C芳烷基或7-11C芳烷基，后三者任选被取代；环X为说明书中定义的杂环；A为亚苯基或5-7C环亚烷基或1-8C亚烷基链，其中任选插入一个或两个基团；R2和R3为说明书中描述的各种基团：及其药学上可接受的酸加成盐。还描述了制造工艺和药物组合物。
• US4748165A
  申请人：——

  公开号：US4748165A

  公开（公告）日：1988-05-31