(2,2-dimethyl-3-oxo-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester | 1150634-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (2,2-dimethyl-3-oxo-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
• 英文别名: 9H-fluoren-9-ylmethyl N-(2,2-dimethyl-3-oxopropyl)carbamate
• CAS: 1150634-11-9
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: KMQGIHMUCMRZTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基-1-(三甲基硅氧基)-1-丙烯 、 ((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl acetate 在 zinc(II) chloride 作用下， 以 四氢呋喃 、 氘代氯仿 为溶剂， 反应 21.0h， 以80%的产率得到(2,2-dimethyl-3-oxo-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
  参考文献：
  名称：

  Addition of Carbon-Based Nucleophiles to Fmoc-Protected Acyl Iminium Ions

  摘要：

  Weakly basic carbon nucleophiles add efficiently to a Fmoc-protected N,O-acetal compound. The new reactions highlight the compatibility of the Fmoc protecting group with moderately basic reaction conditions and should serve as a model for the development of more efficient syntheses of Fmoc-protected amino acids.

  DOI：

  10.1021/jo8027714

文献信息

• NUCLEIC ACID DELIVERY COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Dowdy Steven F.

  公开号：US20120142763A1

  公开（公告）日：2012-06-07

  This disclosure relates to nucleic acid constructs modified to have a reduced net anionic charge. The constructs comprise phosphotriester and/or phosphothioate protecting groups. The disclosure also provides methods of making and using such constructs.
• Addition of Carbon-Based Nucleophiles to Fmoc-Protected Acyl Iminium Ions
  作者：Alison E. Hartman、Cheryl L. Brophy、Julia A. Cupp、Daniel K. Hodge、Timothy J. Peelen

  DOI：10.1021/jo8027714

  日期：2009.5.15

  Weakly basic carbon nucleophiles add efficiently to a Fmoc-protected N,O-acetal compound. The new reactions highlight the compatibility of the Fmoc protecting group with moderately basic reaction conditions and should serve as a model for the development of more efficient syntheses of Fmoc-protected amino acids.