ALA3(glycerol) | 1227675-92-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: ALA3(glycerol)
• CAS: 1227675-92-4
• 化学式: C₂₇H₄₄O₆S₆
• 分子量: 657.039
• InChiKey: SRPDLKRTRMSGOW-WXFUMESZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.13
• 重原子数：
  39.0
• 可旋转键数：
  20.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  78.9
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  甘油 、 R-(+)-硫辛酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到ALA3(glycerol)
  参考文献：
  名称：

  Preparation and characterization of antioxidant nanospheres from multiple α-lipoic acid-containing compounds

  摘要：

  The purpose of this study was to prepare and characterize antioxidant nanospheres composed of multiple alpha-lipoic acid-containing compounds (mALAs). It was found that the nanospheres were remarkably stable under physiologic conditions, maintained the antioxidant property of alpha-lipoic acid, and could be destabilized oxidatively and enzymatically. The preparations were simple and highly reproducible providing a new strategy for the development of nanometer-sized antioxidant biomaterials. The nanospheres may find applications as antioxidant therapeutics and oxidation-responsive antioxidant nanocontainers in drug delivery for pathological conditions characterized by oxidative stress including cancer and neurodegenerative diseases. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.102