2,6-Dichlor-5-isopropylthiomethyl-pyrimidin | 7627-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,6-Dichlor-5-isopropylthiomethyl-pyrimidin
• 英文别名: 2,4-dichloro-5-isopropylsulfanylmethyl-pyrimidine；2,4-Dichloro-5-(propan-2-ylsulfanylmethyl)pyrimidine
• CAS: 7627-47-6
• 化学式: C₈H₁₀Cl₂N₂S
• 分子量: 237.153
• InChiKey: PIGFUCZIYJQCPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：AstraZeneca AB

  公开号：EP2074118A2

  公开（公告）日：2009-07-01
• [EN] COMPOUNDS 945<br/>[FR] COMPOSÉS 945
  申请人：ASTRAZENECA AB

  公开号：WO2009007748A2

  公开（公告）日：2009-01-15

  A compound of formula (I) or a pharamaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in disease mediated by an mTOR kinase and/or one or more PI3K enzyme.