chloromethyl-cycloheptane | 99969-52-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: chloromethyl-cycloheptane
• 英文别名: Chlormethyl-cycloheptan；(Chloromethyl)cycloheptane；chloromethylcycloheptane
• CAS: 99969-52-5
• 化学式: C₈H₁₅Cl
• 分子量: 146.66
• InChiKey: JAXTWASTBIYALB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  chloromethyl-cycloheptane 、 二乙醇胺 在 氯化亚砜 作用下， 生成 bis-(2-chloro-ethyl)-cycloheptylmethyl-amine
  参考文献：
  名称：

  Temporal disjunctive logic programming

  摘要：

  In this paper we introduce the logic programming language Disjunctive Chronology which combines the programming paradigms of temporal and disjunctive logic programming. Disjunctive Chronolog is capable of ex pressing dynamic behaviour as well as uncertainty, two notions that are very common in a variety of real systems. We present the minimal temporal model semantics and the fixpoint semantics for the new programming language and demonstrate their equivalence. We also show how proof procedures developed for disjunctive logic programs can be easily extended to apply to Disjunctive Chronolog programs.

  DOI：

  10.1007/bf03037535
• 作为产物：
  描述：

  环庚烷甲醇 在 氯化亚砜 、 氯仿 作用下， 生成 chloromethyl-cycloheptane
  参考文献：
  名称：

  Temporal disjunctive logic programming

  摘要：

  In this paper we introduce the logic programming language Disjunctive Chronology which combines the programming paradigms of temporal and disjunctive logic programming. Disjunctive Chronolog is capable of ex pressing dynamic behaviour as well as uncertainty, two notions that are very common in a variety of real systems. We present the minimal temporal model semantics and the fixpoint semantics for the new programming language and demonstrate their equivalence. We also show how proof procedures developed for disjunctive logic programs can be easily extended to apply to Disjunctive Chronolog programs.

  DOI：

  10.1007/bf03037535

文献信息

• Orally active indole N-oxide PDE4 inhibitors
  作者：Christopher Hulme、Rose Mathew、Kevin Moriarty、Bruce Miller、Mercy Ramanjulu、Paul Cox、John Souness、Ken M. Page、Joanne Uhl、Jeffrey Travis、Richard Labaudiniere、Fu-chih Huang、Stevan W. Djuric

  DOI：10.1016/s0960-894x(98)00572-1

  日期：1998.11

  and in vivo evaluation of a novel potent series of phosphodiesterase type (IV) (PDE4) inhibitors. Several of the compounds presented possess low nanomolar IC50's for PDE4 inhibition and excellent in vivo activity for inhibition of TNF-alpha levels in LPS challenged mice (mouse endotoxemia model). Emesis studies (dog) and efficacy in a SCW arthritis model for the most potent PDE4 inhibitors are presented

  该交流描述了一系列新型有效的磷酸二酯酶（IV）（PDE4）抑制剂的合成以及体外和体内评估。提出的几种化合物在LPS攻击的小鼠（小鼠内毒素血症模型）中具有低纳摩尔IC50抑制PDE4和出色的体内抑制TNF-α水平的活性。介绍了最有效的PDE4抑制剂在SCW关节炎模型中的呕吐研究（狗）和功效。
• BLANEY, F. E.;CLARK, M. S. G.;GARDNER, D. V.;HADLEY, M. S.;MIDDLETON, D.;+, J. MED. CHEM., 1983, 26, N 12, 1747-1752
  作者：BLANEY, F. E.、CLARK, M. S. G.、GARDNER, D. V.、HADLEY, M. S.、MIDDLETON, D.、+

  DOI：——

  日期：——
• Temporal disjunctive logic programming
  作者：Manolis Gergatsoulis、Panos Rondogiannis、Themis Panayiotopoulos

  DOI：10.1007/bf03037535

  日期：2001.3

  In this paper we introduce the logic programming language Disjunctive Chronology which combines the programming paradigms of temporal and disjunctive logic programming. Disjunctive Chronolog is capable of ex pressing dynamic behaviour as well as uncertainty, two notions that are very common in a variety of real systems. We present the minimal temporal model semantics and the fixpoint semantics for the new programming language and demonstrate their equivalence. We also show how proof procedures developed for disjunctive logic programs can be easily extended to apply to Disjunctive Chronolog programs.