1-(4-nitrophenoxy)-piperidine | 78039-75-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-nitrophenoxy)-piperidine
• 英文别名: 1-(4-Nitrophenoxy)piperidine
• CAS: 78039-75-5
• 化学式: C₁₁H₁₄N₂O₃
• 分子量: 222.244
• InChiKey: BOONUEZCIYFBHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-nitrophenoxy)-piperidine 、 N-(2-nitrophenoxy)piperidine 生成 哌啶
  参考文献：
  名称：

  KHUTHIER, A. -H.;AL-KAZZAZ, A. -K. S.;AL-RAWI, J. M. A.;AL-IRAQI, M. A., J. ORG. CHEM., 1981, 46, N 18, 3634-3638

  摘要：

  DOI：
• 作为产物：
  描述：

  1-p-nitrophenylpiperidine N-oxide 以 1,4-二氧六环 为溶剂， 反应 3.0h， 以97%的产率得到1-(4-nitrophenoxy)-piperidine
  参考文献：
  名称：

  Studies of tertiary amine oxides. 4. Thermal rearrangement of N-aryl amine oxides to O-arylhydroxylamines

  摘要：

  DOI：

  10.1021/jo00331a010

文献信息

• Studies of tertiary amine oxides. 4. Thermal rearrangement of N-aryl amine oxides to O-arylhydroxylamines
  作者：Abdul-Hussain Khuthier、Abdul-Khalik S. Al-Kazzaz、Jasim M. A. Al-Rawi、Mohammed A. Al-Iraqi

  DOI：10.1021/jo00331a010

  日期：1981.8
• Studies in tertiary amine oxides. Part V—carbon-13 nuclear magnetic resonance spectra of someN-aryl tertiary amines, the correspondingN-oxides and the meisenheimer rearrangement products
  作者：Abdul-Hussain Khuthier、Jasim M. A. Al-Rawi、Abdul K. Al-Kazzaz、Mohammed A. Al-Iraqi

  DOI：10.1002/mrc.1270180212

  日期：1982.2

  AbstractThe carbon‐13 NMR spectra of some N‐(2‐ or 4‐nitrophenyl) tertiary amines and their corresponding N‐oxides have been analysed. These N‐oxides undergo thermal rearrangement to O‐arylhydroxylamines, for which the 13C NMR spectral assignments were also carried out. The N‐oxidation effect on the aromatic and aliphatic fragments is calculated.
• KHUTHIER, ABDUL-HUSSAIN;AL-MALLAH, KHAWLA Y.;HANNA, S. Y.;ABDULLA, NOOR-A+, J. ORG. CHEM., 52,(1987) N 9, 1710-1713
  作者：KHUTHIER, ABDUL-HUSSAIN、AL-MALLAH, KHAWLA Y.、HANNA, S. Y.、ABDULLA, NOOR-A+

  DOI：——

  日期：——
• COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF
  申请人：XWPharma Ltd.

  公开号：EP3856719A1

  公开（公告）日：2021-08-04
• [EN] COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF<br/>[FR] COMPOSÉS EN TANT QU'ANTAGONISTES DU RÉCEPTEUR 3 DE L'HISTAMINE NEURONALE ET LEURS UTILISATIONS
  申请人：XW LAB INC

  公开号：WO2020062251A1

  公开（公告）日：2020-04-02

  The present invention relates compounds of Formula (A) as H3R antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of Histamine 3 Receptor (H3R) functions. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to H3R functions in humans.

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