1-(2-羟基苯基)-1-(4-羟基苯基)环己烷 | 71401-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2-羟基苯基)-1-(4-羟基苯基)环己烷
• 英文名称: 1-(2-hydroxyphenyl)-1-(4-hydroxyphenyl)cyclohexane
• 英文别名: 2-[1-(4-Hydroxyphenyl)cyclohexyl]phenol
• CAS: 71401-15-5
• 化学式: C₁₈H₂₀O₂
• 分子量: 268.356
• InChiKey: QEPQVODMZZLBKM-UHFFFAOYSA-N

物化性质

• 沸点：
  428.3±38.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯酚 、 环己酮 生成 1-(2-羟基苯基)-1-(4-羟基苯基)环己烷
  参考文献：
  名称：

  KOZLIKOVSKIJ, YA. B.;CHERNYAEV, B. V., ZH. ORGAN. XIMII, 1984, 20, N 10, 2162-2166

  摘要：

  DOI：

文献信息

• Organized Surface Functional Groups:  Cooperative Catalysis via Thiol/Sulfonic Acid Pairing
  作者：Eric L. Margelefsky、Ryan K. Zeidan、Véronique Dufaud、Mark E. Davis

  DOI：10.1021/ja074761e

  日期：2007.11.1

  synthesis and characterization of heterogeneous catalysts containing surfaces functionalized with discrete pairs of sulfonic acid and thiol groups are reported. A catalyst having acid and thiol groups separated by three carbon atoms is ca. 3 times more active than a material containing randomly distributed acid and thiol groups in the condensation of acetone and phenol to bisphenol A and 14 times more

  报道了含有用不连续的磺酸和硫醇基团对官能化的表面的多相催化剂的合成和表征。具有由三个碳原子隔开的酸和硫醇基团的催化剂是大约。在丙酮和苯酚缩合为双酚 A 时比含有随机分布的酸和硫醇基团的材料活性高 3 倍，在环己酮和苯酚缩合为双酚 Z 时活性高 14 倍。 增加配对材料中的酸/硫醇距离降低活性和选择性。这项工作清楚地揭示了多相催化剂表面上两个不同官能团的纳米级组织的重要性。
• COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS
  申请人：OLSSON Roger

  公开号：US20110046237A1

  公开（公告）日：2011-02-24

  Disclosed herein are methods of treatment and prevention of diseases and disorders related to estrogen receptors comprising administering novel di-aromatic compounds to patients in need thereof.

  本文揭示了一种治疗和预防与雌激素受体相关的疾病和疾病的方法，包括向需要此类治疗的患者施用新型二芳基化合物。
• Kozlikovskii, Ya. B.; Chernyaev, B. V., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 1970 - 1973
  作者：Kozlikovskii, Ya. B.、Chernyaev, B. V.

  DOI：——

  日期：——
• Nanoscale Organization of Thiol and Arylsulfonic Acid on Silica Leads to a Highly Active and Selective Bifunctional, Heterogeneous Catalyst
  作者：Eric L. Margelefsky、Anissa Bendjériou、Ryan K. Zeidan、Véronique Dufaud、Mark E. Davis

  DOI：10.1021/ja804082m

  日期：2008.10.8

  Ordered mesoporous silicas functionalized with alkylsulfonic acid and thiol group pairs have been shown to catalyze the synthesis of bisphenols from the condensation of phenol and various ketones, with activity and selectivity highly dependent on the distance between the acid and thiol. Here, a new route to thiol/sulfonic acid paired catalysts is reported. A bis-silane precursor molecule containing both a disulfide and a sulfonate ester bond is grafted onto the surface of ordered mesoporous silica, SBA-15, followed by simultaneous disulfide reduction and sulfonate ester hydrolysis. The resulting catalyst, containing organized pairs of arylsulfonic acid and thiol groups, is Significantly more active than the alkylsulfonic acid/thiol paired catalyst in the synthesis of bisphenol A and Z, and this increase in activity does not lead to a loss of regioselectivity. The paired catalyst has activity similar to that of a randomly bifunctionalized arylsulfonic acid/thiol catalyst in the bisphenol A reaction but exhibits greater activity and selectivity than the randomly bifunctionalized catalyst in the bisphenol Z reaction.
• JP2011213603A
  申请人：——

  公开号：JP2011213603A

  公开（公告）日：2011-10-27