3-(2-chlorophenyl)-1-(furan-2-yl)-3-(phenylthio)propan-1-one | 1373122-02-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-(2-chlorophenyl)-1-(furan-2-yl)-3-(phenylthio)propan-1-one
• 英文别名: 3-(2-Chlorophenyl)-1-(furan-2-yl)-3-phenylsulfanylpropan-1-one
• CAS: 1373122-02-1
• 化学式: C₁₉H₁₅ClO₂S
• 分子量: 342.846
• InChiKey: KXNXATTYNVEWTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(2-Chlorophenyl)-1-(furan-2-yl)prop-2-en-1-one 、 苯硫酚 在 碘 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以82%的产率得到3-(2-chlorophenyl)-1-(furan-2-yl)-3-(phenylthio)propan-1-one
  参考文献：
  名称：

  Synthesis and Screening Antimicrobial Activities of Novel 1,3-Diaryl-3- (Phenylthio)Propan-1-One Derivatives

  摘要：

  In this study, a series of novel beta-mercapto carbonyl derivatives (3a-j) was prepared by addition of thiophenol (2) to chalcones (1a-j) in the presence of catalytic amount of iodine (10 mol%) in CH2Cl2. Antibacterial and antifungal in vitro properties of the synthesized compounds were tested against some human pathogenic microorganisms by employing the disk diffusion technique. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.

  DOI：

  10.1080/10426507.2011.632387

文献信息

• Synthesis and Screening Antimicrobial Activities of Novel 1,3-Diaryl-3- (Phenylthio)Propan-1-One Derivatives
  作者：İsa Karaman、Hayreddin Gezegen、Mustafa Ceylan、Merve Dilmaç

  DOI：10.1080/10426507.2011.632387

  日期：2012.5

  In this study, a series of novel beta-mercapto carbonyl derivatives (3a-j) was prepared by addition of thiophenol (2) to chalcones (1a-j) in the presence of catalytic amount of iodine (10 mol%) in CH2Cl2. Antibacterial and antifungal in vitro properties of the synthesized compounds were tested against some human pathogenic microorganisms by employing the disk diffusion technique. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.