3-[(N-acetyl-sulfanilyl)-amino]-benzonitrile | 857624-26-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(N-acetyl-sulfanilyl)-amino]-benzonitrile
• 英文别名: N-Acetyl-sulfanilsaeure-(3-cyan-anilid)；N-[4-[(3-cyanophenyl)sulfamoyl]phenyl]acetamide
• CAS: 857624-26-1
• 化学式: C₁₅H₁₃N₃O₃S
• 分子量: 315.353
• InChiKey: YQARIYPNZOKEGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[(N-acetyl-sulfanilyl)-amino]-benzonitrile 在 sodium hydroxide 作用下， 生成 3-sulfanilylamino-benzoic acid
  参考文献：
  名称：

  DE681685

  摘要：

  公开号：
• 作为产物：
  描述：

  间氨基苯甲腈 、 对乙酰胺基苯磺酰氯 在 吡啶 作用下， 生成 3-[(N-acetyl-sulfanilyl)-amino]-benzonitrile
  参考文献：
  名称：

  Midazolam premedication reduces propofol requirements for sedation during regional anesthesia

  摘要：

  Purpose: Propofol is often used for sedation during spinal anesthesia. We investigated the effects of midazolam premedication on the propofol requirements and incidence of complications during sedation.Methods: In a prospective randomized, controlled, and single-blinded study, 50 patients undergoing elective gynecological surgery were randomly divided into control and midazolam groups. Patients in the midazolam group received 2 mg midazolam im 30 min before arrival at the operation room. After spinal anesthesia was instituted with intrathecal injection of hyperbaric tetracaine, we provided sedation using continuous infusion of propofol, The level of sedation was controlled at a level between "eyes closed but reusable to command" and "eyes closed but reusable to mild physical stimulation" by adjusting the infusion rate. During sedation, the propofol requirements and complications were recorded and patients were asked, two hours after the end of operation, whether they remembered intraoperative events.Results: In the midazolam group, the loading dose, steady state infusion rate, and overall infusion rate of propofol were 0.74 mg.kg(-1), 2.86 mg.kg(-1).hr(-1), and 3.32 mg.kg(-1).hr(-1), respectively, which were about 17% lower than those in the control group (P < 0.05). Moreover, midazolam premedication reduced the incidence of intraoperative memory (P < 0.05), but had no effects on other complications.Conclusion: Midazolam premedication reduced propofol requirements and the incidence of intraoperative memory during sedation, These effects on sedation using propofol during spinal anesthesia are considered beneficial for patients.

  DOI：

  10.1007/bf03020731

文献信息

• Copper-Catalyzed Synthesis of Functionalized Aryl Sulfonamides from Sodium Sulfinates in Green Solvents
  作者：Long Yin Lam、King Hong Chan、Cong Ma

  DOI：10.1021/acs.joc.2c00777

  日期：2022.7.1

  industry. A one-step synthesis catalyzed by a copper salt was developed using stable solid commodity chemicals in sulfolane or, alternatively, in green solvents such as γ-valerolactone, iPrOAc, or nBuOAc with acetic acid. The method tolerated diverse functional groups commonly presented in current medicines and drug intermediates. The mechanistic study showed a radical coupling pathway between the sulfonyl

  官能化芳基磺酰胺是制药工业中的重要组成部分。使用稳定的固体商品化学品在环丁砜中或在绿色溶剂（如 γ-戊内酯、 i PrOAc 或n BuOAc 与乙酸）中开发了由铜盐催化的一步合成。该方法耐受当前药物和药物中间体中常见的多种官能团。机理研究表明，磺酰基和苯胺自由基之间的自由基偶联途径分别通过使用 K 2 S 2 O 8和铜催化剂。
• Sulphonic acid amide compound
  申请人：WINTHROP CHEM CO INC

  公开号：US02270676A1

  公开（公告）日：1942-01-20
• 190. Sulphonamides. Part I. The action of ammonia on sulphanilamidobenzoic esters in the light of the general theory of ester ammonolysis
  作者：John H. Gorvin

  DOI：10.1039/jr9450000732

  日期：——
• DE681685
  申请人：——

  公开号：——

  公开（公告）日：——
• Midazolam premedication reduces propofol requirements for sedation during regional anesthesia
  作者：Masashi Nakagawa、Tadanori Mammoto、Ayako Hazama、Takashi Kita、Tetsuya Akamatsu、Noriko Kambara、Toshiko Sakai、Yoshihiko Kishi

  DOI：10.1007/bf03020731

  日期：2000.1

  Purpose: Propofol is often used for sedation during spinal anesthesia. We investigated the effects of midazolam premedication on the propofol requirements and incidence of complications during sedation.Methods: In a prospective randomized, controlled, and single-blinded study, 50 patients undergoing elective gynecological surgery were randomly divided into control and midazolam groups. Patients in the midazolam group received 2 mg midazolam im 30 min before arrival at the operation room. After spinal anesthesia was instituted with intrathecal injection of hyperbaric tetracaine, we provided sedation using continuous infusion of propofol, The level of sedation was controlled at a level between "eyes closed but reusable to command" and "eyes closed but reusable to mild physical stimulation" by adjusting the infusion rate. During sedation, the propofol requirements and complications were recorded and patients were asked, two hours after the end of operation, whether they remembered intraoperative events.Results: In the midazolam group, the loading dose, steady state infusion rate, and overall infusion rate of propofol were 0.74 mg.kg(-1), 2.86 mg.kg(-1).hr(-1), and 3.32 mg.kg(-1).hr(-1), respectively, which were about 17% lower than those in the control group (P < 0.05). Moreover, midazolam premedication reduced the incidence of intraoperative memory (P < 0.05), but had no effects on other complications.Conclusion: Midazolam premedication reduced propofol requirements and the incidence of intraoperative memory during sedation, These effects on sedation using propofol during spinal anesthesia are considered beneficial for patients.