4-溴-2-{[(1-乙基-1H-苯并咪唑-2-基)氨基]甲基}苯酚 | 364748-24-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 4-溴-2-{[(1-乙基-1H-苯并咪唑-2-基)氨基]甲基}苯酚
• 英文名称: 4-bromo-2-{[(1-ethyl-1H-benzimidazol-2-yl)amino]methyl}phenol
• 英文别名: 4-bromo-2-[[(1-ethylbenzimidazol-2-yl)amino]methyl]phenol
• CAS: 364748-24-3
• 化学式: C₁₆H₁₆BrN₃O
• mdl: MFCD02921656
• 分子量: 346.22
• InChiKey: GUVFPFMXZFAHAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  50.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS
  申请人：Verkman Alan S.

  公开号：US20100190796A1

  公开（公告）日：2010-07-29

  Provided herein are methods for identifying and characterizing agents that alter the volume of a cell. Methods are provided for rapid screening and identification of an agent that alters the capability of a small, neutrally charged solute transporter to transport the solute across a cell membrane. The methods described herein may be used to identify and characterize inhibitors of urea transporters, to identify and characterize inhibitors of aquaporins, and to identify and characterize inhibitors of other small, neutrally charged solutes such as glucose.
• US9316633B2
  申请人：——

  公开号：US9316633B2

  公开（公告）日：2016-04-19