2-(2,6-dimethoxy-phenyl)-5-methyl-3-(1-methyl-1H-benzotriazol-5-ylmethyl)-thiazolidin-4-one | 1255932-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 2-(2,6-dimethoxy-phenyl)-5-methyl-3-(1-methyl-1H-benzotriazol-5-ylmethyl)-thiazolidin-4-one
• 英文别名: 2-(2,6-Dimethoxyphenyl)-5-methyl-3-[(1-methylbenzotriazol-5-yl)methyl]-1,3-thiazolidin-4-one
• CAS: 1255932-99-0
• 化学式: C₂₀H₂₂N₄O₃S
• 分子量: 398.486
• InChiKey: GFSKKISPYUHFKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  94.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
  申请人：Aissaoui Hamed

  公开号：US20120088759A1

  公开（公告）日：2012-04-12

  The present invention relates to thiazolidin-4-one and [1,3]-thiazinan-4-one compounds of formula (I) wherein X, Y, R 3 and R 4 are as described in the description, or pharmaceutically acceptable salts thereof, for the prevention or treatment of diseases related to the orexin system. The present invention also relates to novel thiazolidin-4-one compounds of formula (II) and their use as pharmaceuticals, pharmaceutical compositions containing one or more compounds of formula (II), and especially their use as orexin receptor antagonists.

  本发明涉及式（I）的噻唑啉-4-酮和[1,3]-噻唑烷-4-酮化合物，其中X、Y、R3和R4如描述中所述，或其药学上可接受的盐，用于预防或治疗与促进醒觉系统有关的疾病。本发明还涉及式（II）的新型噻唑啉-4-酮化合物及其用作药物、含有一个或多个式（II）化合物的药物组合物，特别是它们作为促进醒觉受体拮抗剂的用途。