(R)-5-(benzyloxy)-3-hydroxypentanoic acid | 591251-75-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-5-(benzyloxy)-3-hydroxypentanoic acid
• 英文别名: (3R)-3-hydroxy-5-phenylmethoxypentanoic acid
• CAS: 591251-75-1
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: YLPJHOCVPPHOLG-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-5-(benzyloxy)-3-hydroxypentanoic acid 在 吡啶 、 4-二甲氨基吡啶 、 溴化锡 、 二异丁基氢化铝 、 scandium tris(trifluoromethanesulfonate) 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  使用1,1-双（（三甲基甲硅烷基）甲基）乙烯丁烯与4-乙酰氧基-1,3-二恶烷聚合合成多元醇链

  摘要：

  对称的双亲核试剂1,1-双（（三甲基甲硅烷基）甲基）乙烯用作连接两个不同的4-乙酰氧基-1,3-二恶烷的关键。这些偶联物产生抗二醇，并用于制备roflamycoin多元醇的链段。发现通常在偶合4-乙酰氧基-1,3-二恶烷上观察到的抗二醇选择性是C2缩醛取代基的函数，并且叔丁基优于甲基。

  DOI：

  10.1016/s0040-4039(98)80014-2
• 作为产物：
  描述：

  (S)-3-[(R)-5 (benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one 在 sodium hydroxide 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以90%的产率得到(R)-5-(benzyloxy)-3-hydroxypentanoic acid
  参考文献：
  名称：

  An efficient strategy for the synthesis of syn 1,3-diols via iterative acetate aldol reactions and synthesis of atorvastatin lactone

  摘要：

  An efficient strategy for the synthesis of syn 1,3-diol has been developed, employing an imidazolidinone based chiral auxiliary via stereoselective and sequential double acetate aldol reactions. The syn 1,3-diol subunit was modified to obtain the C-7 carboxylic acid side chain and further subjected to reaction with a suitable 1,4-diketone under Paal-Knorr conditions to obtain atorvastatin lactone. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.08.011

文献信息

• Structure and method for producing structure, toner containing structure, image forming method and device using toner
  申请人：Yano Tetsuya

  公开号：US20070027291A1

  公开（公告）日：2007-02-01

  A structure, comprising a base material, coated with polymer which can be compatible with reduced load against environment and living organisms and various functionalities is provided. The base material is covered with polyhydroxyalkanoate (PHA). The invention also relates to a method for production of the structure comprising immobilizing the enzyme which synthesize PHA on the surface of the base material, biosynthesizing the PHA and coating the base material. The invention also provides toner containing such the structure and production thereof. Further, the invention relates to an image forming method comprising forming the image by providing such toner to the medium to be recorded.
• [EN] STRUCTURE AND METHOD FOR PRODUCING STRUCTURE, TONER CONTAINING STRUCTURE, IMAGE FORMING METHOD AND DEVICE USING TONER<br/>[FR] STRUCTURE, PROCEDE DE PRODUCTION DE CETTE STRUCTURE, POUDRE D'IMPRESSION CONTENANT UNE TELLE STRUCTURE, PROCEDE DE FORMATION D'IMAGE, ET DISPOSITIF UTILISANT CETTE POUDRE D'IMPRESSION
  申请人：CANON KK

  公开号：WO2004097530A1

  公开（公告）日：2004-11-11

  A structure, comprising a base material, coated with polymer which can be compatible with reduced load against environment and living organisms and various functionalities is provided. The base material is covered with polyhydroxyalkanoate (PHA). The invention also relates to a method for production of the structure comprising immobilizing the enzyme which synthesize PHA on the surface of the base material, biosynthesizing the PHA and coating the base material. The invention also provides toner containing such the structure and production thereof. Further, the invention relates to an image forming method comprising forming the image by providing such toner to the medium to be recorded.
• Convergent synthesis of a polyol chain with 4-acetoxy-1,3-dioxanes using a 1,1-bis((trimethylsilyl)methyl)ethene linchpin
  作者：Scott D. Rychnovsky、Olga Fryszman、Uday R. Khire

  DOI：10.1016/s0040-4039(98)80014-2

  日期：1999.1

  1,1-bis((trimethylsilyl)methyl)ethene, was used as a linchpin to join two different 4-acetoxy-1,3-dioxanes. These couplings produce anti-diols, and were used to prepare a segment of the roflamycoin polyol. The anti-diol selectivity normally observed on coupling 4-acetoxy-1,3-dioxanes was found to be a function of the C2 acetal substituent, and tert-butyl was superior to methyl.

  对称的双亲核试剂1,1-双（（三甲基甲硅烷基）甲基）乙烯用作连接两个不同的4-乙酰氧基-1,3-二恶烷的关键。这些偶联物产生抗二醇，并用于制备roflamycoin多元醇的链段。发现通常在偶合4-乙酰氧基-1,3-二恶烷上观察到的抗二醇选择性是C2缩醛取代基的函数，并且叔丁基优于甲基。
• An efficient strategy for the synthesis of syn 1,3-diols via iterative acetate aldol reactions and synthesis of atorvastatin lactone
  作者：Sandeep Goyal、Bhautikkumar Patel、Ratnesh Sharma、Mangilal Chouhan、Kapil Kumar、Mukesh Gangar、Vipin A. Nair

  DOI：10.1016/j.tetlet.2015.08.011

  日期：2015.9

  An efficient strategy for the synthesis of syn 1,3-diol has been developed, employing an imidazolidinone based chiral auxiliary via stereoselective and sequential double acetate aldol reactions. The syn 1,3-diol subunit was modified to obtain the C-7 carboxylic acid side chain and further subjected to reaction with a suitable 1,4-diketone under Paal-Knorr conditions to obtain atorvastatin lactone. (C) 2015 Elsevier Ltd. All rights reserved.