4-(Benzyloxy)-2-hydroxybutanenitrile | 907956-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(Benzyloxy)-2-hydroxybutanenitrile
• 英文别名: 2-hydroxy-4-phenylmethoxybutanenitrile
• CAS: 907956-67-6
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: KMIYMJQNHUMXPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(Benzyloxy)-2-hydroxybutanenitrile 在 甲醇 、 sodium tetrahydroborate 、 二异丁基氢化铝 作用下， 生成 4-[4-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butylamino]-butan-1-ol
  参考文献：
  名称：

  Synthesis of reduced collagen crosslinks

  摘要：

  A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00252-8
• 作为产物：
  描述：

  3-苄氧基-1-丙醇 在 pyridinium chlorochromate 作用下， 生成 4-(Benzyloxy)-2-hydroxybutanenitrile
  参考文献：
  名称：

  Synthesis of reduced collagen crosslinks

  摘要：

  A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00252-8

文献信息

• Synthesis of reduced collagen crosslinks
  作者：Adrianus M.C.H van den Nieuwendijk、Jorg C.J Benningshof、Volker Wegmann、Ruud A Bank、Johan M te Koppele、Johannes Brussee、Arne van der Gen

  DOI：10.1016/s0960-894x(99)00252-8

  日期：1999.6

  A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.