(N,4-dibenzoylanilino) 3,4-dimethoxybenzoate | 1252084-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (N,4-dibenzoylanilino) 3,4-dimethoxybenzoate
• CAS: 1252084-26-6
• 化学式: C₂₉H₂₃NO₆
• 分子量: 481.505
• InChiKey: DTODQMKOKMFYKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(4-benzoylphenyl)-N-hydroxybenzamide 、 3,4-二甲氧基苯甲酰氯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以92%的产率得到(N,4-dibenzoylanilino) 3,4-dimethoxybenzoate
  参考文献：
  名称：

  N,O-Diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents

  摘要：

  Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using >= 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.116

文献信息

• N,O-Diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents
  作者：Nilanjana Chowdhury、Sansa Dutta、Boda Nishitha、Swagata Dasgupta、N.D. Pradeep Singh

  DOI：10.1016/j.bmcl.2010.07.116

  日期：2010.9

  Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using >= 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents. (c) 2010 Elsevier Ltd. All rights reserved.