N-4-benzoylphenylhydroxylamine | 63064-08-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-4-benzoylphenylhydroxylamine
• 英文别名: [4-(Hydroxyamino)phenyl](phenyl)methanone；[4-(hydroxyamino)phenyl]-phenylmethanone
• CAS: 63064-08-4
• 化学式: C₁₃H₁₁NO₂
• 分子量: 213.236
• InChiKey: RLBTZDKJGNETHY-UHFFFAOYSA-N

物化性质

• 沸点：
  393.9±44.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-4-benzoylphenylhydroxylamine 生成 4-benzoylazobenzene
  参考文献：
  名称：

  槟榔酸。适用于某些亚硝基芳烃的亚硝基保护试剂

  摘要：

  在酸性介质中，砷次磺酸被用作C-亚硝基的保护剂，以防止其还原和缩合，从而导致不可还原的羟胺。脱保护是通过碱性水解进行的。

  DOI：

  10.1039/c3976000820a

文献信息

• ISOXAZOLIDINE DERIVATIVES
  申请人：GHIDINI Eleonora

  公开号：US20120238531A1

  公开（公告）日：2012-09-20

  Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.

  根据此处定义的公式(I)，糖皮质类固醇系列的抗炎和抗过敏化合物对于治疗呼吸道疾病特别有效，这些疾病以气道阻塞为特征。
• N,O-Diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents
  作者：Nilanjana Chowdhury、Sansa Dutta、Boda Nishitha、Swagata Dasgupta、N.D. Pradeep Singh

  DOI：10.1016/j.bmcl.2010.07.116

  日期：2010.9

  Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using >= 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents. (c) 2010 Elsevier Ltd. All rights reserved.
• US8835412B2
  申请人：——

  公开号：US8835412B2

  公开（公告）日：2014-09-16
• [EN] ISOXAZOLIDINE DERIVATIVES<br/>[FR] DÉRIVÉS D'ISOXAZOLIDINE
  申请人：CHIESI FARMA SPA

  公开号：WO2012123493A2

  公开（公告）日：2012-09-20

  The present invention relates to novel anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, methods of preparing such compounds, pharmaceutical compositions comprisingthem, combinations and therapeutic uses thereof. More particularly, the invention relates to glucocorticosteroids that are derivatives of isoxazolidine.
• Arenesulphinic acids. Nitroso protecting reagents applicable to some nitrosoarenes
  作者：Andr� Darchen、Claude Moinet

  DOI：10.1039/c3976000820a

  日期：——

  Arsenesulphinic acids were used, in acidic media, as protecting reagents for the C-nitroso-group against reduction and condensation, leading to a non-reducible hydroxylamine; deprotection is effected by basic hydrolysis.

  在酸性介质中，砷次磺酸被用作C-亚硝基的保护剂，以防止其还原和缩合，从而导致不可还原的羟胺。脱保护是通过碱性水解进行的。