tert-butyl N-[2-[2-[3-(triethylsilyloxymethyl)pentan-3-yl]phenyl]phenyl]carbamate | 219679-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[2-[2-[3-(triethylsilyloxymethyl)pentan-3-yl]phenyl]phenyl]carbamate
• CAS: 219679-02-4
• 化学式: C₂₉H₄₅NO₃Si
• 分子量: 483.767
• InChiKey: KRRVSDOCBVHJGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.78
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[2-[2-[3-(triethylsilyloxymethyl)pentan-3-yl]phenyl]phenyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以95%的产率得到2-(2'-aminobiphenyl-2-yl)-2-ethylbutan-1-ol
  参考文献：
  名称：

  Antimitotic agents interacting with tubulin: Synthesis and structure-activity relationships of novel ortho bridged biphenyls of the rhazinilam type

  摘要：

  Several new ortho bridged biphenyls mimicking the structure of (-)-rhazinilam were synthesized and evaluated as cytotoxic compounds and as inhibitors of microtubules disassembly. These included azadibenzo[a,c]cyclononene derivatives having an ester, urea or carbamate function present in the 9-membered ring linking the two phenyl moieties. The compound bearing a carbamate function instead of the amide group of rhazinilam interacts better with tubulin than (-) rhazinilam, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00903-x
• 作为产物：
  描述：

  2-碘苯基乙腈 在 吡啶 、 sodium tetrahydroborate 、 正丁基锂 、 trans-benzyl(chloro)-bis(triphenylphosphine)palladium(II) 、 二异丁基氢化铝 、 二异丙胺 作用下， 以 甲醇 、 正己烷 、 甲苯 为溶剂， 反应 14.87h， 生成 tert-butyl N-[2-[2-[3-(triethylsilyloxymethyl)pentan-3-yl]phenyl]phenyl]carbamate
  参考文献：
  名称：

  Antimitotic agents interacting with tubulin: Synthesis and structure-activity relationships of novel ortho bridged biphenyls of the rhazinilam type

  摘要：

  Several new ortho bridged biphenyls mimicking the structure of (-)-rhazinilam were synthesized and evaluated as cytotoxic compounds and as inhibitors of microtubules disassembly. These included azadibenzo[a,c]cyclononene derivatives having an ester, urea or carbamate function present in the 9-membered ring linking the two phenyl moieties. The compound bearing a carbamate function instead of the amide group of rhazinilam interacts better with tubulin than (-) rhazinilam, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00903-x

文献信息

• Antimitotic agents interacting with tubulin: Synthesis and structure-activity relationships of novel ortho bridged biphenyls of the rhazinilam type
  作者：Cécile Pascal、Joëlle Dubois、Daniel Guénard、Luba Tchertanov、Sylviane Thoret、Françoise Guéritte

  DOI：10.1016/s0040-4020(98)00903-x

  日期：1998.12

  Several new ortho bridged biphenyls mimicking the structure of (-)-rhazinilam were synthesized and evaluated as cytotoxic compounds and as inhibitors of microtubules disassembly. These included azadibenzo[a,c]cyclononene derivatives having an ester, urea or carbamate function present in the 9-membered ring linking the two phenyl moieties. The compound bearing a carbamate function instead of the amide group of rhazinilam interacts better with tubulin than (-) rhazinilam, (C) 1998 Elsevier Science Ltd. All rights reserved.