6-(2,5-Dimethylfuran-3-yl)-4-methylsulfanyl-2-oxopyran-3-carbonitrile | 939794-53-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-(2,5-Dimethylfuran-3-yl)-4-methylsulfanyl-2-oxopyran-3-carbonitrile
• CAS: 939794-53-3
• 化学式: C₁₃H₁₁NO₃S
• 分子量: 261.301
• InChiKey: RKLXGDBGWYQIRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  88.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-(2,5-Dimethylfuran-3-yl)-4-methylsulfanyl-2-oxopyran-3-carbonitrile 在 PPA 、 水 作用下， 以84%的产率得到6-(2,5-Dimethylfuran-3-yl)-4-methylsulfanyl-2-oxopyran-3-carboxamide
  参考文献：
  名称：

  Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model

  摘要：

  Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2- one and 6-ffuran-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.036
• 作为产物：
  描述：

  3-乙酰基-2,5-二甲基呋喃 、 2-氰-3,3-二(甲硫基)丙烯酸甲酯 在 氢氧化钾 作用下， 以 二甲基亚砜 为溶剂， 以85%的产率得到6-(2,5-Dimethylfuran-3-yl)-4-methylsulfanyl-2-oxopyran-3-carbonitrile
  参考文献：
  名称：

  Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model

  摘要：

  Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2- one and 6-ffuran-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.036

文献信息

• Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model
  作者：Fateh V. Singh、Sumit Chaurasia、Maya D. Joshi、Arvind K. Srivastava、Atul Goel

  DOI：10.1016/j.bmcl.2007.02.036

  日期：2007.5

  Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2- one and 6-ffuran-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model. (C) 2007 Elsevier Ltd. All rights reserved.