(2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(4-(pyridin-3-yl)phenyl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid | 1033806-15-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(4-(pyridin-3-yl)phenyl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid
• 英文别名: (2S)-2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(4-(pyridin-3-yl)phenyl)ethoxy)pyrimidin-4-yl)phenyl)propionic acid；(2S)-2-amino-3-[4-[2-amino-6-[2,2,2-trifluoro-1-(4-pyridin-3-ylphenyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid
• CAS: 1033806-15-3
• 化学式: C₂₆H₂₂F₃N₅O₃
• 分子量: 509.488
• InChiKey: JNXXBYGMCAXNJK-AJZOCDQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• [EN] INDOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'INDOLE
  申请人：RICHTER GEDEON NYRT

  公开号：WO2012059776A1

  公开（公告）日：2012-05-10

  The present invention relates to the indole derivatives of formula (I), wherein R1- R6 and X are defined in the claims and optical antipodes or racemates and/or salts thereof which are selective antagonists of bradykinin B1 to process for producing these compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

  本发明涉及式(I)的吲哒衍生物，其中R1-R6和X在权利要求中定义，并且其光学对映体或消旋体和/或盐是布雷金肽B1的选择性拮抗剂，用于生产这些化合物的方法，含有它们的药物组合物以及它们在治疗或预防疼痛和炎症状况中的使用。
• METHODS OF PREVENTING AND TREATING LOW BONE MASS DISEASES
  申请人：Karsenty Gerard

  公开号：US20110281899A1

  公开（公告）日：2011-11-17

  The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1 inhibitors or serotonin receptor antagonists.

  本发明提供了降低或增加患者血清5-羟色胺水平以增加或减少骨量的方法和治疗剂。在优选实施例中，患者已知患有或有患低骨量疾病（如骨质疏松症）的风险，治疗剂为TPH1抑制剂或5-羟色胺受体拮抗剂。
• [EN] METHODS OF PREVENTING AND TREATING LOW BONE MASS DISEASES<br/>[FR] PROCÉDÉS DE PRÉVENTION ET DE TRAITEMENT DE MALADIES DE FAIBLE MASSE OSSEUSE
  申请人：UNIV COLUMBIA

  公开号：WO2010056992A1

  公开（公告）日：2010-05-20

  The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteoporosis and the agents are TPH1inhibitors or serotonin receptor antagonists.

  本发明提供了降低或增加患者血清5-羟色胺水平的方法和治疗剂，以分别增加或降低骨量。在优选实施例中，患者已知患有或有患低骨量疾病（如骨质疏松症）的风险，治疗剂为TPH1抑制剂或5-羟色胺受体拮抗剂。
• ORAL DOSAGE FORMS COMPRISING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS AND METHODS OF THEIR USE
  申请人：TerSera Therapeutics LLC

  公开号：EP3808740A1

  公开（公告）日：2021-04-21

  Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders.

  本研究公开了式 I 的化合物，以及包含这些化合物的组合物和使用这些化合物治疗、预防和/或控制疾病和失调的方法。
• 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
  申请人：Lexicon Pharmaceuticals, Inc.

  公开号：EP2589600B1

  公开（公告）日：2017-02-15