1-aminocyclopentanecarboxylic acid benzyl ester p.toluenesulfonate | 94912-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-aminocyclopentanecarboxylic acid benzyl ester p.toluenesulfonate
• 英文别名: cycloleucine benzyl ester toluenesulfonate salt；1-aminocyclopentanecarboxylic acid benzyl ester p-toluenesulfonic acid salt；Benzyl 1-aminocyclopentanecarboxylate 4-methylbenzenesulfonate；benzyl 1-aminocyclopentane-1-carboxylate;4-methylbenzenesulfonic acid
• CAS: 94912-71-7
• 化学式: C₇H₈O₃S*C₁₃H₁₇NO₂
• 分子量: 391.488
• InChiKey: JSLBQWTZDSOEJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.24
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-(4-methylsulfonylphenoxy)phenylsulfonyl chloride 、 1-aminocyclopentanecarboxylic acid benzyl ester p.toluenesulfonate 在 N,N-二异丙基乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 生成 benzyl 1-((4-(4-(methylsulfonyl)phenoxy)phenyl)sulfonamido)cyclopentane-1-carboxylate
  参考文献：
  名称：

  EP1466899

  摘要：

  公开号：

文献信息

• [EN] INHIBITOR IMAGING AGENTS<br/>[FR] AGENTS INHIBITEURS D'IMAGERIE
  申请人：AMERSHAM PLC

  公开号：WO2005049005A1

  公开（公告）日：2005-06-02

  The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the sulphonamide hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.

  本发明揭示了一种成像试剂，其中包括一种特定类型的矩阵金属蛋白酶抑制剂（MMPi's），属于磺胺基羟肟类，并标记有成像基团，可用于哺乳动物体内成像和诊断的诊断成像试剂。
• Peptides with pharmaceutical activity
  申请人：Zambon Group, S.p.A.

  公开号：US05145872A1

  公开（公告）日：1992-09-08

  Compounds of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described. The compounds of formula I are inhibitor of enzymatic systems and they are useful in pharmaceutical field.

  本发明描述了公式##STR1##的化合物，其中R、R.sub.1、R.sub.2、R.sub.3、R.sub.4、R.sub.5和n的含义如说明书所述，以及它们的制备过程和含有它们作为活性成分的药物组合物。公式I的化合物是酶系统的抑制剂，它们在制药领域中是有用的。
• Novel urea derivatives
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：US20020198376A1

  公开（公告）日：2002-12-26

  Objects of the present invention are to create compounds having urea structure as basic structure and having a sulfur atom and an amide bond in side chains and to find pharmacological effects thereof, particularly TNF-&agr; production inhibitory effects. The present invention provides compounds represented by the following formula [I] wherein R 1 is H, alkyl, aromatic, R A —CO—, R C —S— or the formula [II]; R 2 , R 3 and R 4 are H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or aromatic; R 5 and R 6 are H, alkyl, alkenyl, cycloalkyl, cycloalkenyl or aromatic; R 5 and R 6 can together form a nonaromatic heterocyclic ring; R7 is H, alkyl, cycloalkyl, hydroxy, mercapto, phenyl, R B —O—, R C —S—, R D —COS—, R E —OCO—, R F —N(R G )— or —CONHOH; and A 1 and A 2 are alkylene. 1

  本发明的目的是创建具有尿素结构作为基本结构并在侧链中具有硫原子和酰胺键的化合物，并发现其药理作用，特别是TNF-α生产抑制作用。本发明提供由以下式子（I）表示的化合物，其中R1为H、烷基、芳香基、RA—CO—、RC—S—或式子（II）；R2、R3和R4为H、烷基、烯基、环烷基、环烯基或芳香基；R5和R6为H、烷基、烯基、环烷基、环烯基或芳香基；R5和R6可以一起形成非芳香杂环；R7为H、烷基、环烷基、羟基、巯基、苯基、RB—O—、RC—S—、RD—COS—、RE—OCO—、RF—N(RG)—或—CONHOH；A1和A2为烷基。
• Aryloxyarylsulfonylamino hydroxamic acid derivatives
  申请人：Pfizer Inc.

  公开号：US06214872B1

  公开（公告）日：2001-04-10

  A compound of the formula wherein X, Y, R1 and R2 are as defined above, useful in the treatment of arthritis or cancer and other diseases involving selective inhibition of matrix metaloproteinase-13.

  该化合物的公式如下，其中X、Y、R1和R2的定义如上所述，可用于治疗关节炎、癌症和其他涉及选择性抑制基质金属蛋白酶-13的疾病。
• Inhibitor imaging agents
  申请人：Cuthbertson Alan

  公开号：US20070104644A1

  公开（公告）日：2007-05-10

  The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the sulphonamide hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.

  本发明揭示了一种成像剂，它包括一种特定类型的矩阵金属蛋白酶抑制剂（MMPi's）的磺酰胺羟肟类，标记有成像部分，用于哺乳动物体内成像和诊断的有用诊断成像剂。