3¹-oxy-6-methoxy-1-methyl-3-propyl-benzene | 199014-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3¹-oxy-6-methoxy-1-methyl-3-propyl-benzene
• 英文别名: α-(4-Methoxy-3-methyl-phenyl)-propylalkohol；α-Oxy-α-(4-methoxy-3-methyl-phenyl)-propan；3¹-Oxy-6-methoxy-1-methyl-3-propyl-benzol；1-(4-Methoxy-3-methylphenyl)propan-1-ol
• CAS: 199014-88-5
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: ROQZGGYRWBWLPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3¹-oxy-6-methoxy-1-methyl-3-propyl-benzene 在 盐酸 、 乙醚 、 乙醇 、 sodium 作用下， 生成 2-methyl-4-propyl-anisole
  参考文献：
  名称：

  Antifungal Pharmacodynamic Characteristics of Amphotericin B againstTrichosporon asahii, Using Time-Kill Methodology

  摘要：

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2002.tb02663.x
• 作为产物：
  描述：

  2-甲基苯甲醚 在 三氯化铝 、 乙醇 、 sodium 、 Petroleum ether 作用下， 生成 3¹-oxy-6-methoxy-1-methyl-3-propyl-benzene
  参考文献：
  名称：

  Antifungal Pharmacodynamic Characteristics of Amphotericin B againstTrichosporon asahii, Using Time-Kill Methodology

  摘要：

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2002.tb02663.x

文献信息

• Inorganic ion receptor active compounds
  申请人：NPS Pharmaceuticals, Inc.

  公开号：US06342532B1

  公开（公告）日：2002-01-29

  The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.

  本发明涉及一种能够调节无机离子受体的一个或多个活性的化合物，以及使用这些化合物治疗疾病或疾患的方法。首选的化合物可以模拟或阻断细胞表面钙受体对细胞外钙离子的影响。