(4S,5R)-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-1-cyclopentene-1-methanol | 701278-18-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4S,5R)-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-1-cyclopentene-1-methanol
• 英文别名: [(4S,5R)-4-phenylmethoxy-5-(phenylmethoxymethyl)cyclopenten-1-yl]methanol
• CAS: 701278-18-4
• 化学式: C₂₁H₂₄O₃
• 分子量: 324.42
• InChiKey: CPLHETXHXCUYPU-SFTDATJTSA-N

物化性质

• 沸点：
  463.1±45.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-methoxy-4-[[(4S,5R)-4-phenylmethoxy-5-(phenylmethoxymethyl)cyclopenten-1-yl]methoxymethyl]benzene 在 水 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以69%的产率得到(4S,5R)-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-1-cyclopentene-1-methanol
  参考文献：
  名称：

  Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation

  摘要：

  使用碳硅氧化法制备恩替卡韦及其新型中间体的工艺。

  公开号：

  US20050272932A1

文献信息

• Process for the Preparation of Entecavir and Novel Intermediates Thereof Via Carbon-Silicon Oxidation
  申请人：Zhou Maotang X.

  公开号：US20100286089A1

  公开（公告）日：2010-11-11

  Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation.

  使用碳硅氧化法制备恩替卡韦及其新型中间体的工艺。
• Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
  申请人：——

  公开号：US20040192912A1

  公开（公告）日：2004-09-30

  Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

  本文披露了制备抗病毒药物恩替卡韦的过程。同时还披露了一种树脂吸附过程，用于分离和纯化恩替卡韦。此外，还披露了用于制备恩替卡韦的各种中间体。
• Process for preparing the antiviral agent [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
  申请人：Pendri R. Yadagiri

  公开号：US20060106216A1

  公开（公告）日：2006-05-18

  Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

  公开了制备抗病毒药物恩替卡韦的工艺。还公开了用于分离和纯化恩替卡韦的树脂吸附工艺。还公开了制备恩替卡韦的各种中间体。
• Process for preparing the antiviral agent [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-3-methylenecyclopentyl]-6H-purin-6-one
  申请人：Bristol-Myers Squibb Company

  公开号：US07541460B2

  公开（公告）日：2009-06-02

  Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

  公开了制备抗病毒药物恩替卡韦的过程。还公开了用于分离和纯化恩替卡韦的树脂吸附过程。还公开了用于制备恩替卡韦的各种中间体。
• Intermediates in the preparation of the antiviral agent [1S-(1α, 3α, 4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxmethyl)-2-methylenecyclopentyl]-6H-purin-6-one
  申请人：Bristol-Myers Squibb Company

  公开号：US07550619B2

  公开（公告）日：2009-06-23

  Intermediates useful in the preparation of the antiviral agent entecavir are disclosed. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various processes useful in the preparation of entecavir are also disclosed.

  本文披露了在制备抗病毒药物恩替卡韦时有用的中间体。同时，还披露了一种用于分离和纯化恩替卡韦的树脂吸附过程。此外，还披露了制备恩替卡韦的各种有用过程。