N,N-diallyl-salicylamide | 100372-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diallyl-salicylamide
• 英文别名: N,N-Diallyl-salicylamid；2-hydroxy-N,N-bis(prop-2-enyl)benzamide
• CAS: 100372-34-7
• 化学式: C₁₃H₁₅NO₂
• mdl: MFCD11130549
• 分子量: 217.268
• InChiKey: SUDLJLFJWDXBIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Process for the Production of Fused, Tricyclic Sulfonamides
  申请人：Dappen Michael S.

  公开号：US20110034691A1

  公开（公告）日：2011-02-10

  The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5-(aryl-sulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinolines. Exemplary methods of the invention include an intra-molecular cyclization step, in which a carbon-nitrogen bond is formed, and which employs a copper-based catalyst that contains at least one organic ligand, such as DMEDA. The invention further provides compounds, which are useful as intermediates in the methods of the invention.

  本发明提供了一种生产熔合的、三环磺酰胺类似物的可扩展或大规模过程的方法，例如取代或未取代的5-（芳基磺酰基）-4,5-二氢-1H-吡唑并[4,3-c]喹啉和5-（杂环芳基磺酰基）-4,5-二氢-1H-吡唑并[4,3-c]喹啉。本发明的示例方法包括一种分子内环化步骤，其中形成一种碳-氮键，并使用至少含有一种有机配体（例如DMEDA）的铜基催化剂。本发明还提供了化合物，其在本发明的方法中作为中间体有用。
• PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES
  申请人：Elan Pharmaceuticals Inc.

  公开号：EP2411388A2

  公开（公告）日：2012-02-01
• [EN] PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES<br/>[FR] PROCÉDÉ DE PRODUCTION DE SULFONAMIDES TRICYCLIQUES FUSIONNÉS
  申请人：ELAN PHARM INC

  公开号：WO2010111418A2

  公开（公告）日：2010-09-30

  The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5- (aryl-sulfonyl)-4,5-dihydro- 1H-pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5- dihydro-1H-pyrazolo[4,3-c]quinolines. Exemplary methods of the invention include an intra-molecular cyclization step, in which a carbon-nitrogen bond is formed, and which employs a copper-based catalyst that contains at least one organic ligand, such as DMEDA. The invention further provides compounds, which are useful as intermediates in the methods of the invention.