2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethanamine | 51132-04-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethanamine
• 英文别名: 2-(2-aminoethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]-pyridine；2-{5H,6H,7H,8H-imidazo[1,2-a]pyridin-2-yl}ethan-1-amine
• CAS: 51132-04-8
• 化学式: C₉H₁₅N₃
• mdl: MFCD09971385
• 分子量: 165.238
• InChiKey: MYXOWMNBLNAPGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)ethanamine 、 4-氯-2-氟苯甲醛 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 18.0h， 生成 1-(1-(4-chloro-2-fluorophenyl)-3,4,6,7,8,9-hexahydroimidazo-[1,2-a:5,4-c′]dipyridin-2(1H)-yl)-2-((2-ethyl-6-methylpyridin-3-yl)-oxy) ethan-1-one
  参考文献：
  名称：

  Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors

  摘要：

  DOI：

  10.1021/acs.jmedchem.3c01454

文献信息

• [EN] TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE<br/>[FR] COMPOSÉS IMIDAZOLE TRICYCLIQUES COMME INHIBITEURS DE LA TRYPTOPHANE HYDROLASE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2015075025A1

  公开（公告）日：2015-05-28

  The present invention relates to compounds of the formula (I), wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

  本发明涉及式(I)的化合物，其中R1a、R1b、R2、R3和X如描述中所述，其制备方法，其药用盐，以及作为药物的用途，含有一个或多个式(I)化合物的药物组合物，制备这种式(I)化合物的方法，特别是它们作为TPH调节剂的用途。
• Tricyclic imidazole compounds as inhibitors of tryptophan hydroxylase
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US10189839B2

  公开（公告）日：2019-01-29

  The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

  本发明涉及式 (I) 的化合物 其中 R1a、R1b、R2、R3 和 X 如描述中所述，涉及它们的制备，涉及它们的药学上可接受的盐，涉及它们作为药物的用途，涉及含有一种或多种式（I）化合物的药物组合物，涉及这种式（I）化合物的制备方法，尤其涉及它们作为 TPH 调节剂的用途。
• TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE
  申请人：Actelion Pharmaceuticals Ltd

  公开号：EP3071567A1

  公开（公告）日：2016-09-28
• TRICYCLIC PIPERIDINE COMPOUNDS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20180155344A1

  公开（公告）日：2018-06-07

  The present invention relates to compounds of the formula (I) wherein R 1a , R 1b , R 2 , R 3 , (R 4 ) n and ring (A) are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.