6-(3,4-difluorobenzyl)-3-(2-fluorophenyl)-1-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione | 1207378-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(3,4-difluorobenzyl)-3-(2-fluorophenyl)-1-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
• 英文别名: 6-[(3,4-Difluorophenyl)methyl]-3-(2-fluorophenyl)-1-methylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
• CAS: 1207378-10-6
• 化学式: C₁₉H₁₂F₃N₅O₂
• 分子量: 399.332
• InChiKey: AABDRHAPTFBCDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  77.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same
  申请人：Showalter H.D. H.

  公开号：US20110166144A1

  公开（公告）日：2011-07-07

  The present disclosure is directed to pyrimidotriazinediones and pyrimidopyrimidinediones having a formula (I), (II), or (III), or a mixture or pharmaceutically acceptable salt or hydrate thereof, and to methods of treating cancer comprising administering the same.
• [EN] PYRIMIDOTRIAZINEDIONES AND PYRIMIDOPYRIMIDINEDIONES AND METHODS OF USING THE SAME<br/>[FR] PYRIMIDOTRIAZINEDIONES ET PYRIMIDOPYRIMIDINEDIONES ET PROCÉDÉS D'UTILISATION
  申请人：UNIV MICHIGAN

  公开号：WO2010014798A2

  公开（公告）日：2010-02-04

  The present disclosure is directed to pyrimidotriazinediones and pyrimidopyrimidinediones having a formula (I), (II), or (III), or a mixture or pharmaceutically acceptable salt or hydrate thereof, and to methods of treating cancer comprising administering the same.