(S)-2-Chloro-1-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)ethanone | 1110767-96-8

• 分子结构分类: 有机化合物
• 英文名称: (S)-2-Chloro-1-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)ethanone
• 英文别名: 2-chloro-1-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]ethanone
• CAS: 1110767-96-8
• 化学式: C₁₇H₂₅ClO₃
• 分子量: 312.837
• InChiKey: CHTFJNXCDBIHRB-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PHARMACEUTICAL COMPOSITION CONTAINING OPTICALLY ACTIVE COMPOUND HAVING THROMBOPOIETIN RECEPTOR AGONIST ACTIVITY, AND INTERMEDIATE THEREFOR
  申请人：Takayama Masami

  公开号：US20100267783A1

  公开（公告）日：2010-10-21

  An optically active 4-phenylthiazole derivative having a thrombopoietin receptor agonist activity and a pharmaceutical composition containing the present compound as an active ingredient are created, and a platelet production regulating agent which can be orally administered is provided. Disclosed is a pharmaceutical composition containing, as an active ingredient, an optically active compound represented by the formula: wherein, R 1 is a halogen atom or C1-C3 alkyloxy; R 2 is C1-C8 alkyl; R 3 is C1-C8 alkyl; R 4 and R 5 are each independently a fluorine atom or chlorine atom; R 6 is C1-C3 alkyl or C1-C3 alkyloxy; * indicates that a carbon atom marked with an asterisk is an asymmetric carbon, a pharmaceutically acceptable salt thereof, or a solvate thereof.

  创造了一种具有血小板生成素受体激动剂活性的光学活性4-苯基噻唑衍生物和含有该化合物作为活性成分的制药组合物，并提供一种可以口服的血小板生成调节剂。公开了一种制药组合物，其包含以下光学活性化合物作为活性成分：其中，R1是卤素原子或C1-C3烷氧基；R2是C1-C8烷基；R3是C1-C8烷基；R4和R5分别是氟原子或氯原子；R6是C1-C3烷基或C1-C3烷氧基；*表示带有星号标记的碳原子是不对称碳，其药学上可接受的盐或其溶剂化物。
• PHARMACEUTICAL COMPOSITION CONTAINING OPTICALLY ACTIVE COMPOUND HAVING THROMBOPOIETIN RECEPTOR AGONIST ACTIVITY AND INTERMEDIATE THEREOF
  申请人：Shionogi&Co., Ltd.

  公开号：EP2184279A1

  公开（公告）日：2010-05-12

  An optically active 4-phenylthiazole derivative having a thrombopoietin receptor agonist activity and a pharmaceutical composition containing the present compound as an active ingredient are created, and a platelet production regulating agent which can be orally administered is provided. Disclosed is a pharmaceutical composition containing, as an active ingredient, an optically active compound represented by the formula: wherein, R1 is a halogen atom or C1-C3 alkyloxy; R2 is C1-C8 alkyl R3 is C1-C8 alkyl R4 and R5 are each independently a fluorine atom or chlorine atom; R6 is C1-C3 alkyl or C1-C3 alkyloxy * indicates that a carbon atom marked with an asterisk is an asymmetric carbon, a pharmaceutically acceptable salt thereof, or a solvate thereof.

  一种具有凝血酶原受体激动剂活性的光学活性 4-苯基噻唑衍生物和一种含有本化合物作为活性成分的药物组合物应运而生，并提供了一种可口服的血小板生成调节剂。 本发明公开了一种药物组合物，该组合物含有由式表示的光学活性化合物作为活性成分： 其中，R1 是卤原子或 C1-C3 烷氧基；R2 是 C1-C8 烷基 R3 是 C1-C8 烷基 R4 和 R5 各自独立地是氟原子或氯原子；R6 是 C1-C3 烷基或 C1-C3 烷氧基 * 表示标有星号的碳原子是不对称碳、 其药学上可接受的盐或其溶液。
• US8530668B2
  申请人：——

  公开号：US8530668B2

  公开（公告）日：2013-09-10
• US8889722B2
  申请人：——

  公开号：US8889722B2

  公开（公告）日：2014-11-18