methyl 2-(furan-2-yl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihydropyrimidin-5-carboxylate | 1040243-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl 2-(furan-2-yl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihydropyrimidin-5-carboxylate
• 英文别名: methyl 2-(furan-2-yl)-4-(2-chloro-4-fluorophenyl)-6-methyl-1,4-dihyropyrimidin-5-carboxylate；Methyl 4-(2-chloro-4-fluorophenyl)-2-(furan-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
• CAS: 1040243-80-8
• 化学式: C₁₇H₁₄ClFN₂O₃
• 分子量: 348.761
• InChiKey: BBHWURXOQUGFRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN MANUFACTURE OF A MEDICAMENT FOR TREATMENT AND PREVENTION OF VIRAL DISEASES
  申请人：Li Song

  公开号：US20100010013A1

  公开（公告）日：2010-01-14

  The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts or hydrates thereof. The present invention further relates to processes for the preparation of the compounds of formula (I) and optical isomers and to use of the compounds of formula (I), isomers, pharmaceutically acceptable salts or hydrates thereof as medicaments, in particular as medicaments for the treatment and prevention of Hepatitis B.

  本发明涉及公式(I)的化合物或其药学上可接受的盐或水合物。本发明还涉及制备公式(I)化合物和光学异构体的过程，以及将公式(I)化合物、异构体、药学上可接受的盐或水合物用作药物的用途，尤其是用于治疗和预防乙型肝炎的药物。
• NEW DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN MANUFACTURES OF PHARMACEUTICAL MEDICAMENTS FOR TREATMENT AND PREVENTION AGAINST VIROSIS
  申请人：Beijing Molecule Science and Technology Co., Ltd.

  公开号：EP2135866B1

  公开（公告）日：2014-07-02
• US8106196B2
  申请人：——

  公开号：US8106196B2

  公开（公告）日：2012-01-31