2-(4-chlorophenyl)-4-ethyl-4,5-dihydrooxazole | 99859-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chlorophenyl)-4-ethyl-4,5-dihydrooxazole
• 英文别名: 2-(4-Chlorphenyl)-4-ethyl-oxazolin；2-(4-chlorophenyl)-4-ethyl-4,5-dihydro-1,3-oxazole
• CAS: 99859-72-0
• 化学式: C₁₁H₁₂ClNO
• 分子量: 209.675
• InChiKey: IEMFMONVMSCOFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-Chlorbenzoylamino)-butanol 在 吡啶 、 对甲苯磺酰氯 作用下， 生成 2-(4-chlorophenyl)-4-ethyl-4,5-dihydrooxazole
  参考文献：
  名称：

  Cyclization of Acylaminoalkanols to 2-Oxazolines¹

  摘要：

  DOI：

  10.1021/ja01493a045

文献信息

• Transition metal and base free synthesis of 2-aryl-2-oxazolines from aldehydes and β-amino alcohols catalysed by potassium iodide
  作者：C. Uma Maheswari、G. Sathish Kumar、M. Venkateshwar

  DOI：10.1039/c4ra08578g

  日期：——

  Synthesis of 2-aryl-2-oxazolines from β-amino alcohols and aldehydes was achieved in good to excellent yield by employing a potassium iodide (KI)–tert-butyl hydroperoxide (TBHP) catalytic system.

  通过使用碘化钾（KI）-叔丁基过氧化氢（TBHP）催化体系，从β-氨基醇和醛中合成2-芳基-2-噁唑酮可获得良好至优异的产率。
• An efficient one-pot synthesis of 2-oxazolines with molecular iodine under ultrasound irradiation
  作者：Nan Xiao、Sen Hao Wang、Ai Ying Zhang、Hong Yang Li、Peng Wang、Wei Li、Bao Hua Chen、Guo Feng Chen、Na Li

  DOI：10.1007/s11164-015-1961-1

  日期：2015.12

  A series of 2-oxazolines were prepared by the condensation of aldehydes with 2-aminoethanol in the presence of molecular iodine and potassium carbonate in t-BuOH at 35–40 °C under ultrasound irradiation. The easy work-up procedure and moderate to good yields are the advantages of this methodology.

  一系列2-噁唑啉是通过在超声照射下，使用分子碘和碳酸钾在t-BuOH中于35-40°C下将醛与2-氨基乙醇缩合反应制备的。这种方法的优点是简单的后处理程序和中等到良好的产率。
• Layered Double Hydroxides as Reusable Catalysts for Cyclocondensation of Amidines and Aminoalcohols: Access to Multi-functionalized Oxazolines
  作者：Shizhuo Lin、Xing Sheng、Xiangyu Zhang、Haibo Liu、Chujun Luo、Shuaishuai Hou、Bin Li、Xiuwen Chen、Yibiao Li、Feng Xie

  DOI：10.1021/acs.joc.1c02696

  日期：2022.1.21

  An efficient catalytic protocol based on reusable MgAl-layered double hydroxides has been developed for the synthesis of multi-functionalized oxazolines via the cyclocondensation of amidines and aminoalcohols. The developed method has a broad substrate scope and excellent functional group tolerance and uses a reusable catalyst. The catalyst can be conveniently recycled by filtration and reused for

  已经开发了一种基于可重复使用的 MgAl 层状双氢氧化物的有效催化方案，用于通过脒和氨基醇的环缩合合成多功能化恶唑啉。所开发的方法具有广泛的底物范围和优异的官能团耐受性，并使用可重复使用的催化剂。该催化剂可方便地通过过滤回收，重复使用至少5次，且无明显失活。此外，以Ru(II)为催化剂，三乙基硅烷为甲硅烷基化试剂对恶唑啉进行选择性邻位C-H甲硅烷基化，证明这是一种方便实用的合成多功能有机硅官能化恶唑啉的方法，具有良好的生物活性。和物理性质。
• A simple synthesis of 2-substituted oxazolines and oxazines
  作者：Agnieszka Cwik、Zoltán Hell、Adrienn Hegedüs、Zoltán Finta、Zoltán Horváth

  DOI：10.1016/s0040-4039(02)00723-2

  日期：2002.5

  beta-Aminoalcohols react with carboxylic acids in the presence of a zeolite, Ersorb-4, resulting in the formation of oxazoline derivatives in good yields. Similarly, 3-aminopropanol and benzoic acid gave the corresponding 2-phenyloxazine. (C) 2002 Elsevier Science Ltd. All rights reserved.