methyl 4-methylphenylphosphinate | 13336-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 4-methylphenylphosphinate
• 英文别名: p-Tolylphosphinsaeure-methylester；1-[Methoxy(oxido)phosphaniumyl]-4-methylbenzene；1-[methoxy(oxido)phosphaniumyl]-4-methylbenzene
• CAS: 13336-55-5
• 化学式: C₈H₁₁O₂P
• 分子量: 170.148
• InChiKey: CPVMDXNBCLLPLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl hypophosphite 、 4-碘甲苯 在 palladium diacetate N-甲基吗啉 、 三苯基膦 、 原甲酸三甲酯 作用下， 以 乙腈 为溶剂， 反应 1.0h， 以80%的产率得到methyl 4-methylphenylphosphinate
  参考文献：
  名称：

  Palladium Catalyzed Preparation of Monoaryl and Diarylphosphinates from Methyl Phosphinate

  摘要：

  现已开发出一种简单有效的单芳基膦酸甲酯制备方法，该方法涉及在叔胺或环氧丙烷（1,2-环氧丙烷）存在下钯催化芳基碘化物与膦酸甲酯的偶联。 尽管膦酸甲酯具有热敏性和水解敏感性，但这一过程与各种官能团兼容，而且产率合理。对称取代的二芳基膦酸盐也可以用两个等量的芳基碘化物来制备。不对称取代的二芳基膦酸盐很容易通过已知的方法从单芳基膦酸盐中获得，或者通过钯催化第二个芳基碘化物的反应，而无需分离从甲基膦酸盐中得到的中间单芳基膦酸盐。

  DOI：

  10.1055/s-1992-26352

文献信息

• PHOSPHO-INDOLES AS HIV INHIBITORS
  申请人：Storer Richard

  公开号：US20090163444A1

  公开（公告）日：2009-06-25

  3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.

  本文介绍了用于治疗逆转录病毒感染，尤其是HIV的3-磷酸吲哚化合物。还包括仅由3-磷酸吲哚衍生物或与一种或多种其他抗逆转录病毒药物组合而成的组合物，其制备过程以及制造包含这些化合物的药物的方法。
• Phosphoindoles as HIV inhibitors
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP1961757A1

  公开（公告）日：2008-08-27

  3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.

  本文描述了用于治疗逆转录病毒感染，特别是艾滋病毒的 3-膦酰吲哚化合物。此外，还包括由 3-膦酰吲哚衍生物单独或与一种或多种其他抗逆转录病毒药物组合而成的组合物、其制备工艺以及制造含有这些化合物的药物的方法。
• Phospho-indoles as HIV inhibitors
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2256124A1

  公开（公告）日：2010-12-01

  3-Phosphoindonle compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.

  本文描述了用于治疗逆转录病毒感染，特别是艾滋病毒的 3-磷吲哚化合物。此外，还包括由 3-磷吲哚衍生物单独或与一种或多种其他抗逆转录病毒药物组合而成的组合物、其制备工艺以及生产含有这些化合物的药物的方法。
• Synthesis of H‐Phosphinates by the UV Light–Mediated Fragmentation‐Related Phosphorylation Using Simple P‐Heterocycles
  作者：Helga Szelke、János Kovács、György Keglevich

  DOI：10.1080/00397910500297404

  日期：2005.11

  Photolysis of aryl-substituted 2,5-dihydrophosphole oxides (5a-e and 8) in the presence of methanol afforded methyl aryl-H-phosphinates (2a-e) in good yields. In the case of 1-ethyl-, cyclohexyl-, or ethoxy-2,5-dihydrophosphole oxides, the reaction was much slower (5f and 5h) or did not take place at all (5g). In such instances, the presence of an additional skeletal methyl group (7) or the use of the more strained 7-phosphanorbornene derivatives (6) promoted the fragmentation-related phosphorylations. Furthermore, the effect of the ring saturation in 8 and the possible extensions to 2-phosphabicyclo[3.1.0]hexanes (10a and 10f), a 1,2-dihydrophosphinine oxide (11), and a 1,2,3,4,5,6-hexahydrophosphinine oxide (12) were also investigated. Model compounds with P-phenyl substituent that are of sufficient ring strain (8, 10a, and 11) could be utilized well.
• PHOSPHOINDOLES AS HIV INHIBITORS
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP1799696B1

  公开（公告）日：2008-11-12