4-氯-6-硝基-1H-苯并咪唑 | 15476-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 4-氯-6-硝基-1H-苯并咪唑
• 英文名称: 4-chloro-6-nitro-1(3)H-benzimidazole
• 英文别名: 4-Chlor-6-nitro-1(3)H-benzimidazol；4-chloro-6-nitro-1H-benzimidazole
• CAS: 15476-97-8
• 化学式: C₇H₄ClN₃O₂
• 分子量: 197.581
• InChiKey: NLQMRTMBHLZMGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-氯-6-硝基-1H-苯并咪唑 在 盐酸 、 tin(ll) chloride 作用下， 生成 (9ci)-7-氯-1H-苯并咪唑-5-胺
  参考文献：
  名称：

  Metabolite Analogs. III. Preparation of Some Benzimidazoles with Substituents on the 4(7)- and 6(5)-Positions¹

  摘要：

  DOI：

  10.1021/ja01621a043
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 4-氯-6-硝基-1H-苯并咪唑
  参考文献：
  名称：

  Metabolite Analogs. III. Preparation of Some Benzimidazoles with Substituents on the 4(7)- and 6(5)-Positions¹

  摘要：

  DOI：

  10.1021/ja01621a043

文献信息

• Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
  申请人：Sun Aiming

  公开号：US20110281908A1

  公开（公告）日：2011-11-17

  Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.

  本文提供了新型分子伴侣热休克蛋白90（Hsp90）抑制剂的类别和制备方法。这些化合物可用于治疗和预防癌症和其他与Hsp90相关的疾病，如炎症和神经退行性疾病。本文还提供了治疗和预防癌症和其他Hsp90相关疾病的方法。该方法包括向患者施用治疗有效量的Hsp90抑制剂。
• [EN] AMINOQUINOLINE DERIVED HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE<br/>[FR] INHIBITEURS DE LA PROTÉINE DE CHOC THERMIQUE 90 DÉRIVÉS D'AMINOQUINOLINE, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV EMORY

  公开号：WO2010042489A2

  公开（公告）日：2010-04-15

  Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided herein are methods of treating and preventing cancer and other Hsp90 related disease. The methods include administering to a subject a therapeutically effective amount of an Hsp90 inhibitor.