3-(1H-benzoimidazol-2-yl)-1,1-diphenyl-urea | 24363-84-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 3-(1H-benzoimidazol-2-yl)-1,1-diphenyl-urea
• 英文别名: 3-(1H-benzimidazol-2-yl)-1,1-diphenylurea
• CAS: 24363-84-6
• 化学式: C₂₀H₁₆N₄O
• 分子量: 328.373
• InChiKey: LDFZGSMBBFZISK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SYMMETRICAL 2-AMINOPHENYL-BENZAZOLYL-5-ACETATE COMPOUNDS AND THEIR USE AS ANTI-HEPARANASE
  申请人：Leadiant Biosciences SA

  公开号：EP3381907A1

  公开（公告）日：2018-10-03

  The present invention relates to symmetrical 2-aminophenyl-benzazolyl-5-acetate compounds of formula (I). Such compounds are endowed with an anti-heparanase activity. The present invention also relates to the use of such compounds as a medicament, in particular for the treatment of diseases and disorders associated with a heparanase activity, and to pharmaceutical compositions comprising the same.

  本发明涉及符合式(I)的对称2-氨基苯基-苯并咪唑-5-乙酸酯化合物。这些化合物具有抗肝素酶活性。本发明还涉及将这些化合物用作药物，特别是用于治疗与肝素酶活性相关的疾病和紊乱，并涉及包含这些化合物的药物组合物。
• [EN] (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY<br/>[FR] COMPOSES DE (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREE ET PROCEDES D'INHIBITION DE L'ACTIVITE DE L'HEPARANASE
  申请人：IMCLONE SYSTEMS INC

  公开号：WO2005042495A1

  公开（公告）日：2005-05-12

  The present invention encompasses heparanase inhibitors, particularly to certain (benzimidazol-2-yl)-phenyl-phenyl-urea derivatives that inhibit heparanase, pharmaceutical compositions that contain the compounds, methods for making the compounds, and methods of treating heparanase-dependent diseases and conditions in mammals by administering a therapeutically effective amount of the compounds to the mammals.

  本发明涉及抑制肝素酶的抑制剂，特别是某些（苯并咪唑-2-基）-苯基-苯基-脲衍生物，这些衍生物可以抑制肝素酶，以及包含这些化合物的制药组合物，制备这些化合物的方法，以及通过向哺乳动物施用治疗有效量的这些化合物来治疗肝素酶依赖性疾病和病况的方法。
• [EN] SYMMETRICAL 2-AMINOPHENYL-BENZAZOLYL-5-ACETATE COMPOUNDS AND THEIR USE AS ANTI-HEPARANASE<br/>[FR] COMPOSÉS SYMÉTRIQUES DE 2-AMINOPHÉNYL-BENZAZOLYL-5-ACÉTATE ET LEUR UTILISATION COMME ANTI-HÉPARANASE
  申请人：LEADIANT BIOSCIENCES SA IN LIQUIDAZIONE

  公开号：WO2018177857A1

  公开（公告）日：2018-10-04

  The present invention relates to symmetrical 2-aminophenyl-benzazolyl-5-acetate compoundsof formula (I). Such compounds are endowed with an anti-heparanase activity. The present invention also relates to the use of such compounds as a medicament, in particular for the treatment of diseases and disorders associated with a heparanase activity, and to pharmaceutical compositions comprising the same.