4-methyl-6-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2H-[1,2,4]triazine-3,5-dione | 1206516-87-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-6-[4-(2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2H-[1,2,4]triazine-3,5-dione
• 英文别名: 4-methyl-6-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-2H-1,2,4-triazine-3,5-dione
• CAS: 1206516-87-1
• 化学式: C₁₆H₁₇F₃N₄O₃
• 分子量: 370.331
• InChiKey: NIUVUIDDICJVFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS<br/>[FR] DÉRIVÉS DE TRIAZINES ET D'URACILES, LEUR PRÉPARATION ET LEURS APPLICATIONS EN THÉRAPEUTIQUE HUMAINE
  申请人：PF MEDICAMENT

  公开号：WO2010006962A1

  公开（公告）日：2010-01-21

  The present invention relates to derivatives of general formula I wherein : - W represents nitrogen, - R1 represents: • a hydrogen or a linear or branched C1-C5 alkyl radical or, • a C1-C3 alkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C1-C3 alcoxy, C3-C6 alkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C1-C3 N-alkylcarbamoyl groups or, • a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C1-C4 alkyl, linear or branched C1-C3 alkoxy groups, • a C6 2-oxocycloalkyl radical - R2 represents a methyl or heptyl, - m, n are equal to 1, - V represents CH2, - X-Y represents -N- (C=O) -, -CH-O-, - Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C1-C4 alkyl groups.

  本发明涉及一般式I的衍生物，其中： - W代表氮， - R1代表： • 氢或直链或支链C1-C5烷基基团，或者 • 被三氟甲基、腈、羟基、C1-C3烷氧基、C3-C6烷氧基烷氧基、吲哚基、噻吩基、氧硫吩基、C1-C3 N-烷基氨基羰基基团取代的C1-C3烷基基团，或者 • 苯基或吡啶基或萘基，或者选择性地被一个或多个卤素原子、硝基、腈、三氟甲基、乙烯、甲硫基、直链或支链C1-C4烷基、直链或支链C1-C3烷氧基基团取代的噻吩基， • C6 2-氧代环烷基基团 - R2代表甲基或庚基， - m，n等于1， - V代表CH2， - X-Y代表-N- (C=O) -，-CH-O-，- Z代表被一个或多个三氟甲基基团、卤素原子或直链C1-C4烷基基团取代的苯基。
• DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS
  申请人：Leroy Isabelle

  公开号：US20110118266A1

  公开（公告）日：2011-05-19

  The present invention relates to derivatives of general formula I wherein: —W represents nitrogen, —R 1 represents: •a hydrogen or a linear or branched C 1 -C 5 alkyl radical or, •a C 1 -C 3 alkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C 1 -C 3 alcoxy, C 3 -C 6 alkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C 1 -C 3 N-alkylcarbamoyl groups or, •a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C 1 -C 4 alkyl, linear or branched C 1 -C 3 alkoxy groups, •a C 6 2-oxocycloalkyl radical—R 2 represents a methyl or heptyl, —m, n are equal to 1, —V represents CH 2 , —X—Y represents —N— (C═O)—, —CH—O—, —Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C 1 -C 4 alkyl groups.

  本发明涉及一般式I的衍生物，其中：-W代表氮，-R1代表：•氢或线性或支链C1-C5烷基基团，或•C1-C3烷基基团，该基团被三氟甲基，腈，羟基，C1-C3烷氧基，C3-C6烷氧基烷氧基，吲哚基，噻吩基，氧代噻吩基，C1-C3N-烷基氨基甲酰基团取代，或•苯基或吡啶基或萘基，或噻吩基，可选地取代一个或多个卤原子，硝基，腈，三氟甲基，乙烯基，甲硫基，线性支链C1-C4烷基，线性或支链C1-C3烷氧基基团，•C62-氧代环烷基基团-R2代表甲基或庚基，-m，n等于1，-V代表CH2，-X-Y代表-N-(C═O)-，-CH-O-，-Z代表一个苯基，该苯基被一个或多个三氟甲基基团，卤原子或线性C1-C4烷基基团取代。
• JP2011528007A
  申请人：——

  公开号：JP2011528007A

  公开（公告）日：2011-11-10
• US8618287B2
  申请人：——

  公开号：US8618287B2

  公开（公告）日：2013-12-31