4-methyl-3-phenethyl-3H-thiazole-2-thione | 55019-79-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-3-phenethyl-3H-thiazole-2-thione
• 英文别名: 3-Phenaethyl-4-methyl-Δ⁴-thiazolin-thion-(2)；4-Methyl-3-(2-phenylethyl)-1,3-thiazole-2-thione
• CAS: 55019-79-9
• 化学式: C₁₂H₁₃NS₂
• 分子量: 235.374
• InChiKey: QCIRBXMLZQFNIZ-UHFFFAOYSA-N

物化性质

• 沸点：
  362.5±35.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  60.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methyl-3-phenethyl-3H-thiazole-2-thione 、 碘甲烷 生成 4-methyl-2-methylsulfanyl-3-phenethyl-thiazolium; iodide
  参考文献：
  名称：

  Datta,K. et al., Bulletin de la Societe Chimique de France, 1974, p. 2135 - 2140

  摘要：

  DOI：
• 作为产物：
  描述：

  phenethyl-dithiocarbamic acid; sodium salt 、 一氯丙酮 生成 4-methyl-3-phenethyl-3H-thiazole-2-thione
  参考文献：
  名称：

  Datta,K. et al., Bulletin de la Societe Chimique de France, 1974, p. 2135 - 2140

  摘要：

  DOI：

文献信息

• PREVENTION AND TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
  申请人：Ohio University

  公开号：US20170196845A1

  公开（公告）日：2017-07-13

  Methods for preventing, treating, and/or reducing the risk of developing non-alcoholic fatty liver disease in a subject in need thereof and pharmaceutical compositions for the prevention or treatment of non-alcoholic fatty liver disease. Methods for inhibiting excessive accumulation of fat in liver tissue. The methods include administering to the subject or contacting the liver tissue with a therapeutically effective amount of at least one compound of General Formula (I) or General Formula (II): or pharmaceutically-acceptable salts or solvates thereof. The pharmaceutical composition includes at least one compound of the General Formula (I) or the General Formula (II) for administration to a subject for the prevention or treatment of non-alcoholic fatty liver disease.