4-环己基苯胺盐酸盐 | 85418-99-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-环己基苯胺盐酸盐
• 英文名称: 4-cyclohexylaniline hydrochloride
• 英文别名: 4-Cyclohexyl-anilin; Hydrochlorid；4-cyclohexylaniline;hydrochloride
• CAS: 85418-99-1
• 化学式: C₁₂H₁₇N*ClH
• 分子量: 211.735
• InChiKey: FHYFKDKKZLZTDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.74
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-环己基苯胺盐酸盐 在 盐酸 作用下， 生成 对环己基苯甲酸
  参考文献：
  名称：

  Neunhoeffer, Journal fur praktische Chemie (Leipzig 1954), 1932, vol. <2> 133, p. 95,105

  摘要：

  DOI：
• 作为产物：
  描述：

  4-环己基-1-硝基苯 在 二乙基硅烷 、 四(3,5-二(三氟甲基)苯基)硼酸钠 、 Co(dppbsa) 、 盐酸 作用下， 以 甲苯 、 乙醚 为溶剂， 以90 %的产率得到4-环己基苯胺盐酸盐
  参考文献：
  名称：

  Co(dppbsa)-catalyzed reductive N,N-dimethylation of nitroaromatics with CO₂ and hydrosilane

  摘要：

  合成了一种新型半夹心 Co（dppbsa）（[Co]），并用于催化硝基芳烃与二氧化碳和氢硅烷的 N,N-二甲基化反应。该催化剂还能高效地将硝基芳烃还原成芳香胺。

  DOI：

  10.1039/d3gc02517a

文献信息

• COMPOUNDS IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3
  申请人：Berg Stefan

  公开号：US20050222181A1

  公开（公告）日：2005-10-06

  The present invention relates to new compounds of formula I wherein R 1 , R 2 , R 3 , n, m are defined as in claim 1, a process for their preparation and new intermediates used in the preparation thereof, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3.

  本发明涉及公式I的新化合物，其中R1、R2、R3、n、m的定义如权利要求书1中所述，以及其制备过程和用于制备新中间体的新中间体，含有所述治疗活性化合物的制药配方以及所述活性化合物在治疗中的应用，特别是在预防和/或治疗与糖原合成酶激酶-3相关的痴呆症、阿尔茨海默病和相关疾病方面的应用。
• 4-alkyl-thiophenyl-ethanolamines, having an activity the cerebral
  申请人：——

  公开号：US04587248A1

  公开（公告）日：1986-05-06

  4-alkyl-thiophenyl-ethanolamines are disclosed, which are compounds having a therapeutical activity against blood-platelet aggregation, and against lipemia and improving the cerebral circulation, said ethanolamines having the general formula: ##STR1## wherein R and R.sub.1 are alkyl substituents and R.sub.2 is a substituent having an amine character. Due to the presence of two asymmetry centers in their molecule, the compounds concerned can be prepared in the "threo" and the "erythro" configuration: mixtures of the "threo" and the "erythro" forms have also proven effective.

  本文披露了4-烷基噻吩基乙醇胺，这些化合物具有治疗血小板聚集、改善脂质血症和脑循环的治疗活性，所述乙醇胺具有通式：##STR1## 其中R和R.sub.1是烷基取代基，R.sub.2是具有胺性质的取代基。由于分子中存在两个不对称中心，因此所述化合物可以在“threo”和“erythro”构型下制备：混合物的“threo”和“erythro”形式也被证明是有效的。
• 4-Alkyl-thiophenyl-ethanolamines, having an activity on the cerebral circulation, the blood platelet-aggregation and the lipemia
  申请人：MAGGIONI FARMACEUTICI S.p.A.

  公开号：EP0066919A1

  公开（公告）日：1982-12-15

  4-alkyl-thiophenyl-ethanolamines are disclosed, which are compounds having a therapeutical activity against blood-platelet aggregation, and against lipemia and improving the cerebral circulation, said ethanolamines having the general formula: wherein R and R, are alkyl substituents and R2 is a substituent having an amine character. Due to the presence of two asymmetry centres in their molecule, the compounds concerned can be prepared in the «threo» and the «erythro» configuration: mixtures of the «threo» and the «erythro» forms have also proven effective.

  本发明公开了 4-烷基-噻吩-乙醇胺，这种化合物具有抗血小板聚集、抗脂血和改善脑循环的治疗活性，所述乙醇胺具有通式： 其中 R 和 R 是烷基取代基，R2 是具有胺性质的取代基。由于其分子中存在两个不对称中心，有关化合物可以制备成 "赤式 "和 "赤式 "构型："赤式 "和 "赤式 "的混合物也被证明是有效的。
• Synthesis of thiophene-2-carboxamidines containing 2-amino-thiazoles and their biological evaluation as urokinase inhibitors
  作者：Kenneth J. Wilson、Carl R. Illig、Nalin Subasinghe、James B. Hoffman、M. Jonathan Rudolph、Richard Soll、Christopher J. Molloy、Roger Bone、David Green、Troy Randall、Marie Zhang、Frank A. Lewandowski、Zhao Zhou、Celia Sharp、Diane Maguire、Bruce Grasberger、Renee L. DesJarlais、John Spurlino

  DOI：10.1016/s0960-894x(01)00102-0

  日期：2001.4

  The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino- 1,3-thiazolyl]-thiophene-2-carboxamidine is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Magnetic and dielectric properties of (CHAn)2MCl4 and (An)2MCl4, where M=Cu or Mn, CHAn=4-cyclohexyl analinium and An=analinium
  作者：M.G. El-Shaarawy

  DOI：10.1016/s0304-8853(00)00338-3

  日期：2000.7

  The magnetic susceptibility chi(M) and the relative permittivity epsilon(r)' for (CHAn)(2)MnCl4, (An)(2)MnCl4, (CHAn)(2)CuCl4 and (An)(2)CuCl4, where CHAn = 4-cyclohexyl analinium and AN = analinium ions have been studied in the temperature range of 80-400 K. The results showed antiferromagnetic character for the Mn-compounds and ferromagnetic character for Cu-compounds. The plots of epsilon(r)'-T and chi(M)-T showed some breaks attributed to dynamic disordering of the organic chains. The results were correlated and discussed in view of the composition as well as the structure of the compounds. (C) 2000 Elsevier Science B.V. All rights reserved.