(((4R,5R)-4-((1S,3S)-5-(benzyloxy)-1-methoxy-3-methylpentyl)-2,2-dimethyl-1,3-dioxan-5-yl)oxy)triethylsilane | 1310357-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (((4R,5R)-4-((1S,3S)-5-(benzyloxy)-1-methoxy-3-methylpentyl)-2,2-dimethyl-1,3-dioxan-5-yl)oxy)triethylsilane
• CAS: 1310357-44-8
• 化学式: C₂₆H₄₆O₅Si
• 分子量: 466.734
• InChiKey: QSCKGXGCGASNFY-VLYJIQRVSA-N

反应信息

• 作为产物：
  描述：

  (((4R,5R)-4-((S)-5-(benzyloxy)-1-methoxy-3-methylpent-2-en-1-yl)-2,2-dimethyl-1,3-dioxan-5-yl)oxy)triethylsilane 在 10 % platinum on carbon 、 氢气 作用下， 以 甲苯 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 6.0h， 生成 (((4R,5R)-4-((1S,3R)-5-(benzyloxy)-1-methoxy-3-methylpentyl)-2,2-dimethyl-1,3-dioxan-5-yl)oxy)triethylsilane 、 (((4R,5R)-4-((1S,3S)-5-(benzyloxy)-1-methoxy-3-methylpentyl)-2,2-dimethyl-1,3-dioxan-5-yl)oxy)triethylsilane
  参考文献：
  名称：

  Synthesis of Key Fragments of Leiodelide A

  摘要：

  The synthesis of all key fragments of the marine macrolide lelodelide A is described. The polyoxygenated northern subunit is derived from D-xylose, while the southern subunit is rapidly assembled via an aldol reaction and Horner-Wadsworth-Emmons olefination. This highly convergent approach will allow for rapid modification and assembly of several isomers of lelodelide A, which may be necessary considering the assignment of leiodelide B has been previously shown to be incorrect.

  DOI：

  10.1021/ol201183f