(R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-6-(cyclopropylmethoxy)picolinamide formate  | 1393802-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-6-(cyclopropylmethoxy)picolinamide formate
• 英文别名: (R)-N-(3-(3-amino-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-5-yl)-4-fluorophenyl)-6-(cyclopropylmethoxy)picolinamide formate；N-[3-[(5R)-3-amino-6,6-difluoro-5-methyl-2,7-dihydro-1,4-oxazepin-5-yl]-4-fluorophenyl]-6-(cyclopropylmethoxy)pyridine-2-carboxamide;formic acid
• CAS: 1393802-26-0
• 化学式: CH₂O₂*C₂₂H₂₃F₃N₄O₃
• 分子量: 494.471
• InChiKey: MHBOBTZXLDWHSQ-ZMBIFBSDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
  申请人：Hilpert Hans

  公开号：US20130040936A1

  公开（公告）日：2013-02-14

  This invention relates to compounds of the formula wherein and R 1 to R 3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

  本发明涉及公式中的化合物，其中R1至R3如本文所述，或其药用可接受的盐。这些化合物是BACE1和/或BACE2抑制剂，可用作药物治疗和/或预防治疗阿尔茨海默病、糖尿病，特别是2型糖尿病，以及其他代谢性疾病。
• 1,4 OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20140323469A1

  公开（公告）日：2014-10-30

  This invention relates to compounds of the formula wherein and R 1 to R 3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

  本发明涉及以下式子的化合物 其中R1到R3如本文所述，或其药学上可接受的盐。这些化合物是BACE1和/或BACE2抑制剂，可用作药物治疗和/或预防治疗阿尔茨海默病、糖尿病，尤其是2型糖尿病和其他代谢性疾病。
• US8815841B2
  申请人：——

  公开号：US8815841B2

  公开（公告）日：2014-08-26