4-hydroxy-isophthalic acid diamide | 108129-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-isophthalic acid diamide
• 英文别名: 4-Hydroxy-isophthalsaeure-diamid；4-Hydroxy-isophthalamid；4-Hydroxybenzene-1,3-dicarboxamide
• CAS: 108129-45-9
• 化学式: C₈H₈N₂O₃
• 分子量: 180.163
• InChiKey: KWFVAICBOFMNKZ-UHFFFAOYSA-N

物化性质

• 熔点：
  278 °C
• 沸点：
  424.7±40.0 °C(Predicted)
• 密度：
  1.438±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  正溴丁烷 、 4-hydroxy-isophthalic acid diamide 在 乙醇 、 potassium carbonate 作用下， 生成 4-butoxy-isophthalic acid diamide
  参考文献：
  名称：

  974. 4-羟基和4-烷氧基-的酰胺异邻苯二甲酸

  摘要：

  DOI：

  10.1039/jr9570004834
• 作为产物：
  描述：

  4-羟基间苯二甲酸二甲酯 在 氨 作用下， 生成 4-hydroxy-isophthalic acid diamide
  参考文献：
  名称：

  974. 4-羟基和4-烷氧基-的酰胺异邻苯二甲酸

  摘要：

  DOI：

  10.1039/jr9570004834

文献信息

• Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0587311A1

  公开（公告）日：1994-03-16

  Compounds of formula (I) : [wherein: R¹ is hydrogen, alkyl, aralkyl, -CORa, -CORb, -CSRa, -CSRb, -SO₂Rb, -CONHRb, -CSNHRb, -CONRbRb or -CSNRbRb; R² is hydrogen or alkyl; R³ is hydrogen, alkylidene, substituted alkyl, or Rb; R⁴ is optionally substituted alkyl, cycloalkyl, or aryl; R⁵ is RbO-, RbRbN-, RbHN-, aralkyloxycarbonyloxy or aralkyloxycarbonylamino, or R⁵ is -(CH₂)p-D-(CH₂)r- [where D is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and p and r are each 0 or an integer from 1 to 5]; A is -(CH₂)m-B-(CH₂)n- [where B is a single bond, carbonyl, oxygen, sulphur, -NH-, -(CH₂=CH₂)- or -NHCO-; and m and n are each 0 or an integer from 1 to 5]; Ra is alkoxy, aralkyloxy, aryloxy or alkoxycarbonyl; Rb is optionally substituted alkyl, cycloalkyl, heterocyclic, aryl or arylalkenyl]; and pharmaceutically acceptable salts and esters thereof and pro-drugs therefor, have the ability to inhibit the activity of HIV protease and may thus be used for the treatment and prophylaxis of AIDS.

  化合物的化学式为(I)：[其中：R¹为氢，烷基，芳基烷基，-CORa，-CORb，-CSRa，-CSRb，-SO₂Rb，-CONHRb，-CSNHRb，-CONRbRb或-CSNRbRb；R²为氢或烷基；R³为氢，烷基亚甲基，取代烷基或Rb；R⁴为可选取代的烷基，环烷基或芳基；R⁵为RbO-，RbRbN-，RbHN-，芳基烷氧羰氧基氧或芳基烷氧羰氨基，或R⁵为-(CH₂)p-D-(CH₂)r- [其中D为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；p和r分别为0或1到5的整数]；A为-(CH₂)m-B-(CH₂)n- [其中B为单键，酰基，氧，硫，-NH-，-(CH₂=CH₂)-或-NHCO-；m和n分别为0或1到5的整数]；Ra为烷氧基，芳基烷氧基，芳氧基或烷氧羰基；Rb为可选取代的烷基，环烷基，杂环，芳基或芳基烷烯基]；以及其药学上可接受的盐和酯以及其前药，具有抑制HIV蛋白酶活性的能力，因此可用于治疗和预防艾滋病。
• Heterocyclic trichloromethyl derivatives, process for their preparation and their use
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0010348A1

  公开（公告）日：1980-04-30

  The invention relates to novel heterocyclic trichloromethyl derivatives, particularly 2-trichloromethyl-substituted quinazoline, benzo (d]-[1,3] -oxazine and benzo[e]-[1,3] -oxazine derivatives, for example 1, 2-dihydro-2 -trichloromethylquinazolin -4-one. The compounds of the invention are at least as effective as prior art trichloromethyl derivatives, which reduce the production of methane during the rumen metabolism of ruminant animals, and increase the formation of propionate at the expense of acetate, and hence improve the animals' rate of growth and their efficiency of food utilisation.

  本发明涉及新型杂环三氯甲基衍生物，特别是2-三氯甲基取代的喹唑啉、苯并(d)-[1,3]-恶嗪和苯并[e]-[1,3]-恶嗪衍生物，例如1，2-二氢-2-三氯甲基喹唑啉-4-酮。本发明的化合物至少与现有技术中的三氯甲基衍生物同样有效，可减少反刍动物瘤胃代谢过程中甲烷的产生，增加丙酸盐的形成，从而提高动物的生长速度和食物利用效率。
• Jacobsen, Chemische Berichte, 1878, vol. 11, p. 374
  作者：Jacobsen

  DOI：——

  日期：——
• Hunt et al., Chemistry and industry, 1955, p. 417
  作者：Hunt et al.

  DOI：——

  日期：——
• WATER-SOLUBLE NEAR-INFRARED ABSORBING COLORING MATTERS AND AQUEOUS INKS CONTAINING SAME
  申请人：Hirota Koji

  公开号：US20110123784A1

  公开（公告）日：2011-05-26

  Coloring matters represented by general formula (1) or salts thereof are simply provided at a low cost as water-soluble coloring matters which exhibit absorption in the near-infrared region. Further, aqueous ink compositions which contain the coloring matters and have excellent storage stability are also provided. In general formula (1), Nc is optionally substituted naphthalocyanine; M is a metal oxide or the like; R 1 and R 2 are each independently hydrogen or the like; A is a crosslinking group; X and Y are each independently substituted arylamino or the like; k is more than 0 but up to 12 (on average); p is 0 to less than 12; the sum of k and p is more than 0 but up to 12; and any two or the three of R 1 , R 2 and A may be united to form a ring.