(p-Aminophenyl)-trimethylammonium | 21248-43-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (p-Aminophenyl)-trimethylammonium
• 英文别名: Benzenaminium, 4-amino-N,N,N-trimethyl-；(4-aminophenyl)-trimethylazanium
• CAS: 21248-43-1
• 化学式: C₉H₁₅N₂
• 分子量: 151.231
• InChiKey: MSHIGWWCLPELSB-UHFFFAOYSA-N

物化性质

• 熔点：
  201 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [4-(2,4-Dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid 、 (p-Aminophenyl)-trimethylammonium 在 polymer-bound morpholine 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以44%的产率得到[4-[[2-[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetyl]amino]phenyl]-trimethylazanium
  参考文献：
  名称：

  Design, Synthesis, and Structure−Activity Relationships of 1-,3-,8-, and 9-Substituted-9-deazaxanthines at the Human A_2B Adenosine Receptor

  摘要：

  Over two hundred 1-, 3-, 8-, and 9-substituted-9-deazaxanthines were prepared and evaluated for their binding affinity at the recombinant human adenosine receptors, in particular at the hA(2B) and hA(2A) subtypes. Several ligands endowed with sub-micromolar to low nanomolar binding affinity at hA(2B) receptors, good selectivity over hA(2A) and hA(3), but a relatively poor selectivity over hA(1) were obtained. Good antagonistic potencies and efficacies, with pA(2) values close to the corresponding pK(i)s, were observed in functional assays in vitro performed on a selected series of compounds. 1,3-Dimethyl-8-phenoxy-(N-p-halogenophenyl)-acetamido-9-deazaxanthine derivatives appeared as the most interesting leads, some of them showing outstanding hA(2B) affinities, high selectivity over hA(2A) and hA(3), but low selectivity over hA(1). Structure-affinity relationships suggested that the binding potency at the hA(2B) receptor was mainly modulated by the steric (lipophilic) properties of the substituents at positions 1 and 3 and by the electronic and lipophilic characteristics of the substituents at position 8. A comparison among affinity and selectivity profiles of 9-deazaxanthines with the corresponding xanthines suggested some possible differences in their binding mode.

  DOI：

  10.1021/jm0506221

文献信息

• Dye mixtures of fiber reactive azo dyes, production and use
  申请人：Eichhorn Joachim

  公开号：US20050223508A1

  公开（公告）日：2005-10-13

  The invention relates to reactive dye mixtures containing one or several dyes of general formula (I), one or several dyes of general formula (II) and, optionally, one or several dyes or general formula (IIIa)-(IIIf), wherein D 1 -D 8 , R, R 1 —R 39 , Z, Z 1 -Z 3 and M have the meaning as cited in claim 1. The invention also relates to the production and the use thereof in order to dye and print fibrous material containing hydroxy and/or carbonamide groups.

  本发明涉及一种反应染料混合物，其中包含一种或多种通式（I）的染料，一种或多种通式（II）的染料，以及可选地一种或多种通式（IIIa）-（IIIf）的染料，其中D1-D8，R，R1-R39，Z，Z1-Z3和M的含义如权利要求书中所述。本发明还涉及其制备和用途，用于染色和印刷含有羟基和/或碳酰胺基团的纤维材料。
• Coloured compound containing a cationic group and a reactive group
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0212807A2

  公开（公告）日：1987-03-04

  A coloured compound containing a cationic group and a cellulose reactive group, especially a compound of the formula: or wherein A is the cationic group; Y is a chromophore; Y' is a cationic chromophore and B is the reactive group, which is suitable for the preparation of a protein absorbent or precipitant for use in the separation of mixtures of proteins.

  一种含有阳离子基团和纤维素活性基团的有色化合物，特别是式 或 其中 A 是阳离子基团 Y 是发色团 Y' 是阳离子发色团，以及 B 是活性基团、 适用于制备蛋白质吸收剂或沉淀剂，用于分离蛋白质混合物。
• METHOD FOR LABELLING A BIOLOGICAL TARGETING MOLECULE VIA CONJUGATION WITH A RADIOISOTOPE SUITABLE FOR PET OR SPECT IMAGING
  申请人：GE Healthcare Limited

  公开号：EP3395373A1

  公开（公告）日：2018-10-31

  The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling via an aminooxy group a biological targeting molecule bearing an aldehyde or keto group with a radioisotope. The method of the invention is particularly suitable for use with an automated synthesizer apparatus. Also provided are precursors in sterile form, as well as cassettes comprising such precursors useful in the method.

  本发明涉及用于体内成像的放射性药物领域，尤其涉及一种通过氨基氧基将带有醛基或酮基的生物靶向分子标记为放射性同位素的方法。本发明的方法特别适用于自动合成装置。此外，本发明还提供了无菌形式的前体，以及包含用于该方法的此类前体的盒。
• DERIVES CHIMIQUES ET LEUR APPLICATION COMME AGENTS ANTITELOMERASE
  申请人：Aventis Pharma S.A.

  公开号：EP1373252A1

  公开（公告）日：2004-01-02
• FARBSTOFFMISCHUNGEN VON FASERREAKTIVEN AZOFARBSTOFFEN, DEREN HERSTELLUNG UND IHRE VERWENDUNG
  申请人：DyStar Textilfarben GmbH & Co. Deutschland KG

  公开号：EP1490442A1

  公开（公告）日：2004-12-29