6-ethoxy-3,4-dihydro-2H-pyran-2-carboxylic acid | 1238189-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 6-ethoxy-3,4-dihydro-2H-pyran-2-carboxylic acid
• CAS: 1238189-33-7
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: INPUDGZZIKEZNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  正丁醛 、 丙烯酸乙酯 在 三乙胺 作用下， 以 正庚烷 、 甲苯 为溶剂， 反应 12.0h， 以37.4%的产率得到乙基4-氧代庚酸酯
  参考文献：
  名称：

  Synthesis of thermoregulated phase-separable triazolium ionic liquids catalysts and application for Stetter reaction

  摘要：

  A series of polyether-substituted triazolium ionic liquids catalysts have been first synthesized for resolving the problem of separation and reuse of Stetter catalysts The catalysts possess the properties of critical solution temperature (CST) and inverse temperature-dependent solubility in toluene/heptane solvents Based on these properties the catalysts can achieve the catalytic process named as thermo-regulated phase-separable catalysis (TPSC) with the characteristic of homogeneous reaction at higher temperature and phase-separation at lower temperature The novel TPSC system has been successfully applied for Stetter reaction of furfural or butanal with ethyl acrylate The experimental results have showed that the novel catalysts exhibit excellent TPSC with high recycling efficiency (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.09.094

文献信息

• Polyether-substituted thiazolium ionic liquid catalysts – a thermoregulated phase-separable catalysis system for the Stetter reaction
  作者：Fengli Yu、Ruili Zhang、Congxia Xie、Shitao Yu

  DOI：10.1039/b921796g

  日期：——

  A series of polyether-substituted thiazolium ionic liquids have been synthesized and used as catalysts in the Stetter reaction. The ionic liquids are a thermoregulated phase-separable catalysis (TPSC) system, because they possess the properties of critical solution temperature (CST) and inverse temperature-dependent solubility in toluene–heptane. The results showed that the novel TPSC system exhibits high recycling efficiency, and provides a potential route for a environmentally benign Stetter reaction.

  一系列聚醚取代的噻唑鎓离子液体已被合成并用作STetter反应的催化剂。这些离子液体是一种热调节相分离催化（TPSC）系统，因为它们具有临界溶液温度（CST）和在甲苯-己烷中逆温度依赖溶解度的特性。结果显示，这种新型TPSC系统具有高回收效率，并为环保的STetter反应提供了一种潜在的途径。