4-甲基-2-(2-甲基丙基)-2H-四氢吡喃-4-醇 | 63500-71-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 中文名称: 4-甲基-2-(2-甲基丙基)-2H-四氢吡喃-4-醇
• 中文别名: 拂柔撒
• 英文名称: 2-(2-methylpropyl)-4-hydroxy-4-methyl-tetrahydropyran
• 英文别名: (tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran-4-ol)；2-isobutyl-4-hydroxy-4-methyltetrahydropyran；2-isobutyl-4-methyl-tetrahydro-2H-pyran-4-ol；2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol；2-Isobutyl-4-methyl-tetrahydropyrane-4-ol；florosa；2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)-；4-methyl-2-(2-methylpropyl)oxan-4-ol
• CAS: 63500-71-0
• 化学式: C₁₀H₂₀O₂
• mdl: MFCD00169854
• 分子量: 172.268
• InChiKey: YVSNOTITPICPTB-UHFFFAOYSA-N

物化性质

• 沸点：
  93-95 °C(Press: 3 Torr)
• 密度：
  0.9516 g/cm3
• LogP：
  1.65 at 23℃
• 物理描述：
  Liquid
• 保留指数：
  1200

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 4-甲基-2-(2-甲基丙基)-2H-四氢吡喃-4-醇 在 camphor-10-sulfonic acid 、 Graphite 作用下， 以 neat (no solvent) 为溶剂， 反应 1.0h， 以80%的产率得到florol acetate
  参考文献：
  名称：

  无溶剂乙酰化程序

  摘要：

  (2021)。无溶剂乙酰化程序。国际有机制剂和程序：卷。53，第 6 期，第 590-594 页。

  DOI：

  10.1080/00304948.2021.1977575
• 作为产物：
  描述：

  4-chlorotetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran 在 双氧水 作用下， 反应 24.0h， 以61%的产率得到4-甲基-2-(2-甲基丙基)-2H-四氢吡喃-4-醇
  参考文献：
  名称：

  Arakelyan, A. S.; Dvoryanchikov, A. I.; Gevorkyan, A. A., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, # 11, p. 2047 - 2050

  摘要：

  DOI：

文献信息

• Fragrance
  申请人：KRAFT Philip

  公开号：US20110039755A1

  公开（公告）日：2011-02-17

  A method of providing to a fragrance application a musky odour, comprising the addition thereto of at least one compound according to the formula I in which R 1 is selected from H and CH 3 ; R 2 , R 3 are selected from the possibilities that (a) both are CH 3 ; and (b) R 2 and R 3 together form a single bond (as indicated by the broken line); and n is an integer selected from 1, 2, 3, and 4. The compounds are useful in the complete range of fine and functional fragrance applications.

  提供给香水应用程序一种提供麝香气味的方法，包括向其中添加至少一种符合以下式I的化合物 其中 R 1 从H和CH 3 中选择； R 2 ，R 3 从以下可能性中选择：(a) 两者都是CH 3 ；和 (b) R 2 和R 3 一起形成一个单键(如虚线所示)；以及 n是从1、2、3和4中选择的整数。 这些化合物在各种精致和功能性香水应用中都很有用。
• [EN] 3-(2-ALKOXYCARBONYLOXY-PHENYL) ACRYLIC ACID ESTERS AND THEIR USE AS PRECURSORS FOR THE DELIVERY OF OLFACTORY COMPOUNDS<br/>[FR] ESTERS D'ACIDE 3-(2-ALCOXYCARBONYLOXY-PHENYL) ACRYLIQUE ET LEUR UTILISATION COMME PRECURSEURS POUR L'ADMINISTRATION DE COMPOSES OLFACTIFS
  申请人：GIVAUDAN SA

  公开号：WO2005077881A1

  公开（公告）日：2005-08-25

  A compound of formula (I), their use as precursors and a method of their production wherein n, Y, R, R2, R3, and R4 has the same meaning as given in the specification.

  一种具有式（I）的化合物，它们作为前体的用途以及它们的制备方法，其中n、Y、R、R2、R3和R4的含义与规范中给出的含义相同。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• [EN] ESTERS AND ETHERS OF 2,2,4,4-TETRAMETHYLCYCLOBUTANE-1,3-DIOL FOR USE AS AROMA CHEMICALS<br/>[FR] ESTERS ET ÉTHERS DE 2,2,4,4-TÉTRAMÉTHYLCYCLOBUTANE -1,3-DIOL DESTINÉS À ÊTRE UTILISÉS EN TANT QUE PRODUITS CHIMIQUES AROMATIQUES
  申请人：BASF SE

  公开号：WO2019048544A1

  公开（公告）日：2019-03-14

  The present invention relates to the use of a compound of the general formula (I) wherein R1 is C1-C4-alkyl or -(C=0)-R3, R2 is hydrogen, C1-C4-alkyl or -(C=0)-R4, and R3 and R4, independently of one another, are selected from the group consisting of hydrogen and C1-C4-alkyl, a stereoisomer thereof or a mixture of stereoisomers thereof, as an aroma chemical, to aroma chemical compositions comprising at least one compound of the general formula (I), a stereoisomer thereof or a mixture of stereoisomers thereof, and to a method for preparing a fragranced ready-to-use composition, which comprises incorporating at least one compound of the general formula (I), a stereoisomer thereof or a mixture of stereoisomers thereof, into a ready- to-use composition. The present invention further relates to specific ethers and specific esters of the compounds of the general formula (I) and a method for their preparation.

  本发明涉及使用一般式(I)的化合物，其中R1是C1-C4-烷基或-(C=0)-R3，R2是氢、C1-C4-烷基或-(C=0)-R4，R3和R4彼此独立地选自氢和C1-C4-烷基的群，其立体异构体或其立体异构体混合物，作为香料化学品，以及包含至少一种一般式(I)的化合物、其立体异构体或其立体异构体混合物的香料化学品组合物，以及制备香味即用组合物的方法，该方法包括将至少一种一般式(I)的化合物、其立体异构体或其立体异构体混合物纳入即用组合物中。本发明还涉及一般式(I)化合物的特定醚和特定酯以及它们的制备方法。
• DERIVATIVES OF 1-(4-METHYLCYCLOHEXYL)-ETHANOLS
  申请人：Symrise AG

  公开号：US20170002294A1

  公开（公告）日：2017-01-05

  The invention relates to mixtures having: components (a) having at least one fragrance of the formula (I) where R1=OC-R2, CH 2 OR3, C1-C8 open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, with R2=an open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, having 2-10 C atoms, with R3=an open-chain or branched aliphatic radical, optionally substituted and/or unsaturated, having 1-8 C atoms, and components (b) having at least one fragrance, different from the fragrances of component a, characterized in that the weight ratio of all components (a) to all components (b) is from 1:10 to 1:10000.

  该发明涉及具有以下特征的混合物：组分(a)至少具有一个符合以下式(I)的香料，其中R1=OC-R2，CH2OR3，C1-C8开链或支链脂肪基，可选择地取代和/或不饱和，其中R2=一个开链或支链脂肪基，可选择地取代和/或不饱和，含有2-10个碳原子，其中R3=一个开链或支链脂肪基，可选择地取代和/或不饱和，含有1-8个碳原子，以及组分(b)至少具有一个与组分a的香料不同的香料，其特征在于所有组分(a)与所有组分(b)的重量比为1:10至1:10000。