2-benzyl-1-phenethyl-2-imidazoline | 3533-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyl-1-phenethyl-2-imidazoline
• 英文别名: 2-Benzyl-1-phenethylimidazoline-2；2-benzyl-1-phenethyl-4,5-dihydro-1H-imidazole；2-Benzyl-1-phenethyl-4,5-dihydro-1h-imidazole；2-benzyl-1-(2-phenylethyl)-4,5-dihydroimidazole
• CAS: 3533-38-8
• 化学式: C₁₈H₂₀N₂
• 分子量: 264.37
• InChiKey: BIUCVTHDWQJWSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(phenylethynyl)aziridine 、 2-苯乙胺 以 乙腈 为溶剂， 反应 30.0h， 以55%的产率得到2-benzyl-1-phenethyl-2-imidazoline
  参考文献：
  名称：

  1-（苯基乙炔基）氮丙啶与胺反应

  摘要：

  DOI：

  10.1007/bf00482491

文献信息

• Novel synthesis of 2-benzyl-2-imidazolines from 1-(phenylethynyl)-aziridine and primary amines
  作者：D. A. Tikhomirov、N. M. Porchinskaya、A. V. Eremeev

  DOI：10.1007/bf00476551

  日期：1987.10
• TIXOMIROV, D. A.;PORCHINSKAYA, N. M.;EREMEEV, A. V., XIMIYA GETEROTSIKL. SOED.,(1989) N, S. 600-603
  作者：TIXOMIROV, D. A.、PORCHINSKAYA, N. M.、EREMEEV, A. V.

  DOI：——

  日期：——
• TIXOMIROV, D. A.;PORCHINSKAYA, N. M.;EREMEEV, A. V., XIMIYA GETEROTSIKL. SOED.,(1987) N 10, 1419-1420
  作者：TIXOMIROV, D. A.、PORCHINSKAYA, N. M.、EREMEEV, A. V.

  DOI：——

  日期：——
• Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
  申请人：Fogarty Patrick

  公开号：US20080312201A1

  公开（公告）日：2008-12-18

  Methods of using methotrexate (MTX) active agents in which reduced host toxicity is observed are provided. In the subject methods, an effective amount of an MTX active agent is administered to the host in conjunction with the administration of an MTX toxicity reducing agent of the present invention. Also provided are compositions for use in practicing the subject methods, e.g., pharmaceutical compositions having reduced toxicity, in which the MTX active agent is combined with an MTX toxicity reducing agent that reduces the level of undesired MTX toxicity while maintaining an effective MTX anti-proliferative activity. Also provided are methods of using the subject methods and compositions in the treatment of a variety of different disease conditions.
• 1-(Phenylethynyl)aziridine in reactions with amines
  作者：D. A. Tikhomirov、N. M. Porchinskaya、A. V. Eremeev

  DOI：10.1007/bf00482491

  日期：1989.5