1,4-Bis-(p-sulfanilyl)-piperazin | 62707-60-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-Bis-(p-sulfanilyl)-piperazin
• 英文别名: 1,4-bis-(4-amino-benzenesulfonyl)-piperazine；1,4-disulfanilyl-piperazine；1,4-Disulfanilyl-piperazin；4,4'-(Piperazine-1,4-diyldisulfonyl)dianiline；4-[4-(4-aminophenyl)sulfonylpiperazin-1-yl]sulfonylaniline
• CAS: 62707-60-2
• 化学式: C₁₆H₂₀N₄O₄S₂
• 分子量: 396.491
• InChiKey: OTFRTALIXHKBEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  144
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,4-Bis-(p-sulfanilyl)-piperazin 、 5-imino-3-methyl-1-phenyl-Δ²-pyrazolin-4-dithiocarbamic acid 在 盐酸 、 sodium nitrite 、 sodium hydroxide 作用下， 以 水 、 丙酮 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  HETEROCYCLO-SUBSTITUTED SULFA DRUGS: PART X. NOVEL 5-IMINO-δ²-PYRAZOLIN-4-DITHIOCARBAMYL-AZO DYES AS ANTIMICROBIAL AGENTS

  摘要：

  Synthesis of a series of novel azo-sulfa drugs as 5-imino-3-methyl-1-phenyl-Delta(2)-pyrazolin-4-dithiocarbamy-azo dyes (I-XV) are described via a reaction of 4-sulfamoyl and/or sulfonyl diazonium chloride with 5-imino-3-methyl 1-1-phenyl-Delta(2)-pyrazolin-4-dithiocarbam acid in acid medium. The corresponding iron, copper, mercury, cobalt, nickel, and lead chelates were obtained in 1:1 ligand-to-metal cation molar ratio at ice temperature as monochelate compounds (Iaf-XVaf). Furthermore, heating in 1:2 molar ratio gave di-chelate compounds (I'a-f-XV'a-f). All the synthesized azo-sulfa drugs (ligands) and their mono- and/or di-chelates were characterized by microanalysis, UV,IR and H-NMR spectroscopy and were screened in vitro for their antibacterial and antifungal activities.

  DOI：

  10.1080/10426509608046407
• 作为产物：
  描述：

  对乙酰胺基苯磺酰氯 在 氢氧化钾 、 sodium hydroxide 、 乙醚 作用下， 生成 1,4-Bis-(p-sulfanilyl)-piperazin
  参考文献：
  名称：

  38.磺胺的吡啶和哌嗪衍生物

  摘要：

  DOI：

  10.1039/jr9400000202

文献信息

• HASSAN KH. M.; ATTA F. M., INDIAN. J. CHEM., 1978, B 16, NO 12, 1073-1075
  作者：HASSAN KH. M.、 ATTA F. M.

  DOI：——

  日期：——
• HETEROCYCLO-SUBSTITUTED SULFA DRUGS: PART X. NOVEL 5-IMINO-δ²-PYRAZOLIN-4-DITHIOCARBAMYL-AZO DYES AS ANTIMICROBIAL AGENTS
  作者：Ibrahim M. A. Awad

  DOI：10.1080/10426509608046407

  日期：1996.7.1

  Synthesis of a series of novel azo-sulfa drugs as 5-imino-3-methyl-1-phenyl-Delta(2)-pyrazolin-4-dithiocarbamy-azo dyes (I-XV) are described via a reaction of 4-sulfamoyl and/or sulfonyl diazonium chloride with 5-imino-3-methyl 1-1-phenyl-Delta(2)-pyrazolin-4-dithiocarbam acid in acid medium. The corresponding iron, copper, mercury, cobalt, nickel, and lead chelates were obtained in 1:1 ligand-to-metal cation molar ratio at ice temperature as monochelate compounds (Iaf-XVaf). Furthermore, heating in 1:2 molar ratio gave di-chelate compounds (I'a-f-XV'a-f). All the synthesized azo-sulfa drugs (ligands) and their mono- and/or di-chelates were characterized by microanalysis, UV,IR and H-NMR spectroscopy and were screened in vitro for their antibacterial and antifungal activities.
• 38. Pyridine and piperazine derivatives of sulphanilamide
  作者：William O. Kermack、Walter Tebrich

  DOI：10.1039/jr9400000202

  日期：——