1-Methyl-N-<2-hydroxy-ethyl>-cytosin | 1129-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Methyl-N-<2-hydroxy-ethyl>-cytosin
• 英文别名: N⁴-(β-Hydroxyaethyl)-1-methylcytosin；4-(2-hydroxy-ethylamino)-1-methyl-1H-pyrimidin-2-one；4-(2-Hydroxyethylamino)-1-methylpyrimidin-2-one
• CAS: 1129-57-3
• 化学式: C₇H₁₁N₃O₂
• 分子量: 169.183
• InChiKey: JWJBIOPMAFKJDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  64.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] CONJUGATES OF GUIDE RNA-CAS PROTEIN COMPLEX<br/>[FR] CONJUGUÉS DE COMPLEXE ARN GUIDE-PROTÉINE CAS
  申请人：ZHONG MINGHONG

  公开号：WO2021034373A1

  公开（公告）日：2021-02-25

  Provided herein are compositions of conjugates of a guide RNA(s)-CRISPR Cas protein (RNP) complex. The conjugate comprises a guide RNA(s)-CRISPR Cas protein (RNP) complex and one or more molecules selected from PEG, non-PEG polymers, ligands for cellular receptors, lipids, oligonucleotides, polysaccharides and peptides and chemically linked to the Cas protein and/or guide RNA(s). The conjugates are delivered to targeted cells as RNP complexes, or formed in targeted cells from guide RNA conjugates and a mRNA or a viral vector encoding a Cas protein, or formed in targeted cells from a crRNA conjugates and a viral vector encoding both a Cas protein and a tracrRNA. Also provided are preparation methods and uses of these conjugates.