N-(9,10-dimethoxy-4-oxo-2-phenyl-6,7-dihydrobenzo[a]quinolizin-3-yl)benzamide | 1365899-66-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(9,10-dimethoxy-4-oxo-2-phenyl-6,7-dihydrobenzo[a]quinolizin-3-yl)benzamide
• CAS: 1365899-66-6
• 化学式: C₂₈H₂₄N₂O₄
• 分子量: 452.51
• InChiKey: WBJMWHVESJLMPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-benzylidene-2-phenyloxazole-5(4H)-one 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 2.5h， 生成 N-(9,10-dimethoxy-4-oxo-2-phenyl-6,7-dihydrobenzo[a]quinolizin-3-yl)benzamide
  参考文献：
  名称：

  Synthesis of benzoindoloquinolizines via a Cu(I)-mediated C–N bond formation

  摘要：

  An effective synthesis of the multi ring-fused benzoindoloquinolizines has been accomplished by Cu(I)-mediated and MW-assisted C-N-amide bond formation of benzo[a]quinolizin-4-ones. The deamination of tetrahydro-2H-pyrido[2,1-a]isoquinolines was also studied and was found to give benzoquinolizines. The benzoialquinolizin-4-ones were prepared based on the annulations of C-1 substituted 3,4-dihydroisoquinolines and azlactones. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.094

文献信息

• Synthesis of benzoindoloquinolizines via a Cu(I)-mediated C–N bond formation
  作者：Rattana Worayuthakarn、Prattya Nealmongkol、Somsak Ruchirawat、Nopporn Thasana

  DOI：10.1016/j.tet.2012.01.094

  日期：2012.4

  An effective synthesis of the multi ring-fused benzoindoloquinolizines has been accomplished by Cu(I)-mediated and MW-assisted C-N-amide bond formation of benzo[a]quinolizin-4-ones. The deamination of tetrahydro-2H-pyrido[2,1-a]isoquinolines was also studied and was found to give benzoquinolizines. The benzoialquinolizin-4-ones were prepared based on the annulations of C-1 substituted 3,4-dihydroisoquinolines and azlactones. (C) 2012 Elsevier Ltd. All rights reserved.