6-(2-Phenylethyl)amino-4-pyridin-4-yl-1H-[1,3,5]triazin-2-one | 1202683-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(2-Phenylethyl)amino-4-pyridin-4-yl-1H-[1,3,5]triazin-2-one
• 英文别名: 6-phenethylamino-4-pyridin-4-yl-1H-[1,3,5]triazin-2-one；4-(2-phenylethylamino)-6-pyridin-4-yl-1H-1,3,5-triazin-2-one
• CAS: 1202683-56-4
• 化学式: C₁₆H₁₅N₅O
• 分子量: 293.328
• InChiKey: SJFWJCVBISYKKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  78.7
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• SUBSTITUTED TRIAZINONE DERIVATIVES
  申请人：LOCHEAD Alistair

  公开号：US20110144114A1

  公开（公告）日：2011-06-16

  Triazinone derivatives represented by formula (I) wherein: Z, R1, R2, R3, R4, and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.

  公式（I）所代表的Triazinone衍生物，其中：Z，R1，R2，R3，R4和n如所述。还披露了制备公式（I）化合物的方法以及它们在治疗中的用途。
• 4-(pyridin-4-yl)-1H-[1,3,5]triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases
  申请人：sanofi-aventis

  公开号：EP2138488A1

  公开（公告）日：2009-12-30

  A triazinone derivative represented by formula (I) wherein: wherein: Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, a C1-6 alkoxy group; R1 represents a 4-pyridine ring; R2 represents a hydrogen atom, a C1-6 alkyl; R3 represents a hydrogen atom, a C1-6 alkyl group; R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted; R4 represents: a phenyl ring, being optionally substituted; n represents 0 to 2; in form of a free base or of an addition salt with an acid. These compounds are useful as GSK3-β inhibitors.

  一种三嗪酮衍生物，由式（I）表示，其中：其中：Z代表键合物，羰基基团，一个亚甲基基团，该亚甲基基团可选地被一或两个选择自C1-6烷基，羟基，C1-6烷氧基的基团取代; R1代表4-吡啶环；R2代表氢原子，C1-6烷基；R3代表氢原子，C1-6烷基团；R2和R3可以一起形成一个6元环，该6元环带有氮原子，R2和R3可选地被取代；R4代表：苯环，可选地被取代；n代表0到2；以游离碱或与酸形成的加合盐的形式存在。这些化合物可用作GSK3-β抑制剂。
• 4-(PYRIDIN-4-YL)-1H-[1,3,5]TRIAZIN-2-ONE DERIVATIVES AS GSK3-BETA INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2321295A2

  公开（公告）日：2011-05-18
• US8592580B2
  申请人：——

  公开号：US8592580B2

  公开（公告）日：2013-11-26
• [EN] SUBSTITUTED TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE SUBSTITUÉS
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2009156860A2

  公开（公告）日：2009-12-30

  A triazinone derivative represented by formula (I) wherein: Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, a C1-6 alkoxy group; R1 represents a 4-pyridine ring; R2 represents a hydrogen atom, a C1-6 alkyl; R3 represents a hydrogen atom, a C1-6 alkyl group; R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted; R4 represents: a phenyl ring, being optionally substituted; n represents 0 to 2; in form of a free base or of an addition salt with an acid. Use in therapeutic.