[(2R)-3-[2-aminooxyethoxy(phenylmethoxy)phosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate | 1071948-00-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: [(2R)-3-[2-aminooxyethoxy(phenylmethoxy)phosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate
• CAS: 1071948-00-9
• 化学式: C₄₄H₈₀NO₉P
• 分子量: 798.094
• InChiKey: XQXMBAQUVWLZHD-UZEJVGCBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  55
• 可旋转键数：
  43
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  133
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  [(2R)-3-[2-aminooxyethoxy(phenylmethoxy)phosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate 、 2-咪唑甲醛 以 甲醇 、 氯仿 为溶剂， 反应 2.0h， 以77%的产率得到
  参考文献：
  名称：

  Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation

  摘要：

  A method for introduction of various head groups on phospholipid frameworks via oxime bond formation has been developed for the synthesis of cyclen-Cu(II), pyrene, naphthalene, and other headgroup functionalized phospholipids that can cleave the membrane protein, hemagglutinin.

  DOI：

  10.1021/ol8019346
• 作为产物：
  描述：

  [(2R)-3-[2-(1,3-dioxoisoindol-2-yl)oxyethoxy-phenylmethoxyphosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate 在 甲基肼 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以91%的产率得到[(2R)-3-[2-aminooxyethoxy(phenylmethoxy)phosphoryl]oxy-2-hexadecanoyloxypropyl] hexadecanoate
  参考文献：
  名称：

  Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation

  摘要：

  A method for introduction of various head groups on phospholipid frameworks via oxime bond formation has been developed for the synthesis of cyclen-Cu(II), pyrene, naphthalene, and other headgroup functionalized phospholipids that can cleave the membrane protein, hemagglutinin.

  DOI：

  10.1021/ol8019346

文献信息

• Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation
  作者：Takumi Furuta、Masayoshi Mochizuki、Mai Ito、Tadanobu Takahashi、Takashi Suzuki、Toshiyuki Kan

  DOI：10.1021/ol8019346

  日期：2008.11.6

  A method for introduction of various head groups on phospholipid frameworks via oxime bond formation has been developed for the synthesis of cyclen-Cu(II), pyrene, naphthalene, and other headgroup functionalized phospholipids that can cleave the membrane protein, hemagglutinin.