3,6-Epoxy-2-methyl-cyclohexan-carbonsaeure | 90199-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 3,6-Epoxy-2-methyl-cyclohexan-carbonsaeure
• 英文别名: 3-methyl-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid；3-Methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
• CAS: 90199-74-9
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: AIORMVLRBXAYKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PROSTAGLANDIN E RECEPTOR ANTAGONISTS
  申请人：Woodward David F.

  公开号：US20100256385A1

  公开（公告）日：2010-10-07

  The present invention provides prostaglandin receptor antagonist compounds represented by the general formula I, wherein A, R, R 1 and R 2 are as defined in the specification.

  本发明提供了由一般式I表示的前列腺素受体拮抗剂化合物，其中A、R、R1和R2如规范中所定义。
• Malic enzyme inhibitors
  申请人：SUN PHARMA ADVANCED RESEARCH COMPANY LTD

  公开号：US11225480B2

  公开（公告）日：2022-01-18

  The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans. The novel compounds have a structure according to Formula I or a pharmaceutically acceptable salt, stereoisomer or deuterated analog thereof, wherein X, R1, R2 and Y are as described herein.

  本发明涉及可用作苹果酸酶（ME）抑制剂的新型化合物、其制备工艺以及这些化合物用于治疗由ME介导的疾病，如人类癌症（如胰腺导管腺癌（PDAC））。这些新型化合物具有符合式 I 的结构 或其药学上可接受的盐、立体异构体或氚代类似物，其中 X、R1、R2 和 Y 如本文所述。
• MALIC ENZYME INHIBITORS
  申请人：Sun Pharma Advanced Research Company Ltd

  公开号：US20220127266A1

  公开（公告）日：2022-04-28

  The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.